Angiogenic factor with G patch and FHA domains 1 is a protein that in humans is encoded by the AGGF1gene.[5][6][7]
AGGF1 is a human gene that functions as an angiogenic factor with a G-patch and forkhead-associated domain.[8] This gene is predominantly expressed in activated, plump endothelial cells and acts to regulate angiogenesis and vascular development.[9] AGGF1 is known to interact with a wide range of proteins involved in vascular development.[10] Mutations to AGGF1 have been implicated in multiple cancers and is known to cause the rare congenital condition, Klippel-Trenaunay syndrome.[9][11][12]
^Gutierrez S, Magano L, Delicado A, Mori MA, de Torres ML, Fernández L, Palomares M, Fernández E, Tarduchy GR, Molano J, Gracia R, Pajares IL, Lapunzina P (December 2006). "The G397A (E133K) change in the AGGF1 (VG5Q) gene is a single nucleotide polymorphism in the Spanish population". American Journal of Medical Genetics. Part A. 140 (24): 2832–3. doi:10.1002/ajmg.a.31532. PMID17103452. S2CID19068189.
^Wang W, Li GY, Zhu JY, Huang DB, Zhou HC, Zhong W, Ji CS (April 2015). "Overexpression of AGGF1 is correlated with angiogenesis and poor prognosis of hepatocellular carcinoma". Medical Oncology. 32 (4): 131. doi:10.1007/s12032-015-0574-2. PMID25796501. S2CID25099244.
