AH-7921

AH-7921
Clinical data
Other namesAH-7921
Routes of
administration		Recreational: insufflation, sublingual, intravenous, oral, rectal[1]
ATC code
  • none
Legal status
Legal status

In General Unscheduled, Illegal in Sweden, Czech Republic, China, Brazil and Israel.

Identifiers
  • 3,4-dichloro-N-{[1-(dimethylamino)cyclohexyl]methyl}benzamide
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC16H22Cl2N2O
Molar mass329.27 g·mol−1
3D model (JSmol)
  • ClC1=CC=C(C(NCC2(CCCCC2)N(C)C)=O)C=C1Cl
  • InChI=1S/C16H22Cl2N2O/c1-20(2)16(8-4-3-5-9-16)11-19-15(21)12-6-7-13(17)14(18)10-12/h6-7,10H,3-5,8-9,11H2,1-2H3,(H,19,21) checkY
  • Key:JMZROFPPEXCTST-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

AH-7921 (Doxylam) is an opioid analgesic drug selective for the μ-opioid receptor, having around 90% the potency of morphine when administered orally.[2][3][4] It was discovered in the 1970s[5] by a team at Allen and Hanburys located in the United Kingdom.[6] The drug is considered a new psychoactive substance (NPS) in which it is synthetically created in laboratories to mimic that of controlled substances. The substance has also been sold on the internet since 2012 as a "research chemical".[1] When sold online it may be called the alternative name doxylam, not to be confused with doxylamine.[7] AH-7921 has never progressed to clinical trials.[8] The DEA is not aware of any medical usage in the United States, and has not insisted the Health and Human Services department (HHS) to conduct any medical research of the substance's uses.[6]

  1. ^ a b Katselou M, Papoutsis I, Nikolaou P, Spiliopoulou C, Athanaselis S (2015). "AH-7921: the list of new psychoactive opioids is expanded". Forensic Toxicology. 33 (2): 195–201. doi:10.1007/s11419-015-0271-z. PMC 4525185. PMID 26257832.
  2. ^ Brittain RT, Kellett DN, Neat ML, Stables R (September 1973). "Proceedings: Anti-nociceptive effects in N-substituted cyclohexylmethylbenzamides". British Journal of Pharmacology. 49 (1): 158P–159P. doi:10.1111/j.1476-5381.1973.tb08279.x. PMC 1776456. PMID 4207044.
  3. ^ Hayes AG, Tyers MB (July 1983). "Determination of receptors that mediate opiate side effects in the mouse". British Journal of Pharmacology. 79 (3): 731–736. doi:10.1111/j.1476-5381.1983.tb10011.x. PMC 2044905. PMID 6317119.
  4. ^ Harper NJ, Veitch GB, Wibberley DG (November 1974). "1-(3,4-Dichlorobenzamidomethyl)cyclohexyldimethylamine and related compounds as potential analgesics". Journal of Medicinal Chemistry. 17 (11): 1188–1193. doi:10.1021/jm00257a012. PMID 4416926.
  5. ^ US patent 3975443, Harper N, Veitch G, "1-(3,4-Dichlorobenzamidomethyl)-cyclohexyldimethylamine", issued 1976-08-17, assigned to Allen & Hanburys 
  6. ^ a b "2016 - Final Order: Placement of AH-7921 Into Schedule I". www.deadiversion.usdoj.gov. Retrieved 2017-12-03.
  7. ^ Zawilska JB (2017-06-30). "An Expanding World of Novel Psychoactive Substances: Opioids". Frontiers in Psychiatry. 8: 110. doi:10.3389/fpsyt.2017.00110. PMC 5492455. PMID 28713291.
  8. ^ Krasowski MD, Brown J, eds. (10 January 2017). "The New Wave of Designer Drugs". Forensic Scholars Today. Concordia University, St. Paul Online. Retrieved 2017-12-03.