AH receptor-interacting protein

AIP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LKN, 4AIF, 4APO
Identifiers
Aliases	AIP, ARA9, FKBP16, FKBP37, SMTPHN, XAP-2, XAP2, aryl hydrocarbon receptor interacting protein, PITA1
External IDs	OMIM: 605555; MGI: 109622; HomoloGene: 2959; GeneCards: AIP; OMA:AIP - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	67,491,154 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	4,175,858 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; popliteal artery; ; tibial arteries; ; Descending thoracic aorta; ; right coronary artery; ; ascending aorta; ; left coronary artery; ; canal of the cervix; ; body of uterus; ; muscle layer of sigmoid colon;
	Top expressed in
	neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; granulocyte; ; quadriceps femoris muscle; ; yolk sac; ; muscle tissue; ; skeletal muscle tissue; ; cerebellum; ; hypothalamus; ; olfactory bulb;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; signal transducer activity; transcription coregulator activity; unfolded protein binding; transcription factor binding; GAF domain binding; transcription coactivator activity; aryl hydrocarbon receptor binding; peptidyl-prolyl cis-trans isomerase activity;
Cellular component	aryl hydrocarbon receptor complex; membrane; plasma membrane; cytosol; nucleoplasm; cytoplasm;
Biological process	protein targeting to mitochondrion; negative regulation of cyclic-nucleotide phosphodiesterase activity; regulation of protein kinase A signaling; protein maturation by protein folding; xenobiotic metabolic process; interleukin-12-mediated signaling pathway; regulation of nucleic acid-templated transcription; positive regulation of nucleic acid-templated transcription; protein peptidyl-prolyl isomerization;
	Sources:Amigo / QuickGO
Orthologs
	9049
	11632
	ENSG00000110711
	ENSMUSG00000024847
	O00170
	O08915
	NM_003977; NM_001302959; NM_001302960
	NM_001276284; NM_016666
	NP_001289888; NP_001289889; NP_003968
	NP_001263213; NP_057875
	Wikidata
View/Edit Human	View/Edit Mouse

AH receptor-interacting protein (AIP) also known as aryl hydrocarbon receptor-interacting protein, immunophilin homolog ARA9, or HBV X-associated protein 2 (XAP-2) is a protein that in humans is encoded by the AIP gene.^[5]^[6]^[7] The protein is a member of the FKBP family.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000110711 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024847 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: AIP aryl hydrocarbon receptor interacting protein".
^ Kuzhandaivelu N, Cong YS, Inouye C, Yang WM, Seto E (December 1996). "XAP2, a novel hepatitis B virus X-associated protein that inhibits X transactivation". Nucleic Acids Res. 24 (23): 4741–50. doi:10.1093/nar/24.23.4741. PMC 146319. PMID 8972861.
^ Carver LA, Bradfield CA (April 1997). "Ligand-dependent interaction of the aryl hydrocarbon receptor with a novel immunophilin homolog in vivo". J. Biol. Chem. 272 (17): 11452–6. doi:10.1074/jbc.272.17.11452. PMID 9111057.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000110711 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024847 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: AIP aryl hydrocarbon receptor interacting protein".

[pmid8972861-6] Kuzhandaivelu N, Cong YS, Inouye C, Yang WM, Seto E (December 1996). "XAP2, a novel hepatitis B virus X-associated protein that inhibits X transactivation". Nucleic Acids Res. 24 (23): 4741–50. doi:10.1093/nar/24.23.4741. PMC 146319. PMID 8972861.

[pmid9111057-7] Carver LA, Bradfield CA (April 1997). "Ligand-dependent interaction of the aryl hydrocarbon receptor with a novel immunophilin homolog in vivo". J. Biol. Chem. 272 (17): 11452–6. doi:10.1074/jbc.272.17.11452. PMID 9111057.

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