AKT3

AKT3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2X18
Identifiers
Aliases	AKT3, MPPH, MPPH2, PKB-GAMMA, PKBG, PRKBG, RAC-PK-gamma, RAC-gamma, STK-2, AKT serine/threonine kinase 3
External IDs	OMIM: 611223; MGI: 1345147; HomoloGene: 55904; GeneCards: AKT3; OMA:AKT3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	243,851,079 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	177,085,769 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; ganglionic eminence; ; epithelium of colon; ; ventricular zone; ; popliteal artery; ; tibial arteries; ; sural nerve; ; islet of Langerhans; ; smooth muscle tissue; ; right coronary artery;
	Top expressed in
	zygote; ; tail of embryo; ; dentate gyrus of hippocampal formation granule cell; ; facial motor nucleus; ; secondary oocyte; ; ganglionic eminence; ; substantia nigra; ; ascending aorta; ; medial dorsal nucleus; ; subdivision of hippocampus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; protein serine/threonine kinase activity; protein binding; ATP binding; kinase activity;
Cellular component	intracellular anatomical structure; membrane; nucleus; cytoplasm;
Biological process	protein phosphorylation; intracellular signal transduction; peptidyl-serine phosphorylation; mitochondrial genome maintenance; signal transduction; phosphorylation; positive regulation of TOR signaling; positive regulation of cell size; brain morphogenesis; homeostasis of number of cells within a tissue; positive regulation of endothelial cell proliferation; positive regulation of blood vessel endothelial cell migration; positive regulation of angiogenesis; positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of vascular endothelial cell proliferation; positive regulation of artery morphogenesis; negative regulation of cellular senescence;
	Sources:Amigo / QuickGO
Orthologs
	10000
	23797
	ENSG00000117020; ENSG00000275199
	ENSMUSG00000019699
	Q9Y243
	Q9WUA6
	NM_001206729; NM_005465; NM_181690; NM_001370074
	NM_011785
	NP_001193658; NP_005456; NP_859029; NP_001357003
	NP_035915
	Wikidata
View/Edit Human	View/Edit Mouse

RAC-gamma serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT3 gene.^[5]^[6]

^ ^a ^b ^c ENSG00000275199 GRCh38: Ensembl release 89: ENSG00000117020, ENSG00000275199 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019699 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Brodbeck D, Cron P, Hemmings BA (Apr 1999). "A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain". J Biol Chem. 274 (14): 9133–6. doi:10.1074/jbc.274.14.9133. PMID 10092583.
^ Nakatani K, Sakaue H, Thompson DA, Weigel RJ, Roth RA (Jun 1999). "Identification of a human Akt3 (protein kinase B gamma) which contains the regulatory serine phosphorylation site". Biochem Biophys Res Commun. 257 (3): 906–10. doi:10.1006/bbrc.1999.0559. PMID 10208883.

[refGRCh38Ensembl-1] ENSG00000275199 GRCh38: Ensembl release 89: ENSG00000117020, ENSG00000275199 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019699 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10092583-5] Brodbeck D, Cron P, Hemmings BA (Apr 1999). "A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain". J Biol Chem. 274 (14): 9133–6. doi:10.1074/jbc.274.14.9133. PMID 10092583.

[pmid10208883-6] Nakatani K, Sakaue H, Thompson DA, Weigel RJ, Roth RA (Jun 1999). "Identification of a human Akt3 (protein kinase B gamma) which contains the regulatory serine phosphorylation site". Biochem Biophys Res Commun. 257 (3): 906–10. doi:10.1006/bbrc.1999.0559. PMID 10208883.

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