ALPI

ALPI
Identifiers
Aliases	ALPI, IAP, alkaline phosphatase, intestinal
External IDs	OMIM: 171740; MGI: 87984; HomoloGene: 134333; GeneCards: ALPI; OMA:ALPI - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	232,460,753 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	87,055,634 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; duodenum; ; mucosa of ileum; ; mucosa of transverse colon; ; rectum; ; human kidney; ; muscle tissue; ; smooth muscle tissue; ; appendix; ; gallbladder;
	Top expressed in
	duodenum; ; embryo; ; jejunum; ; temporal muscle; ; upper arm; ; secretory cell; ; colon; ; triceps brachii muscle; ; mucous cell of stomach; ; midbrain tectum;
	More reference expression data
	n/a
Gene ontology
Molecular function	protease binding; phosphatase activity; zinc ion binding; protein binding; catalytic activity; hydrolase activity; magnesium ion binding; metal ion binding; alkaline phosphatase activity;
Cellular component	integral component of membrane; anchored component of membrane; membrane; extracellular region; plasma membrane;
Biological process	metabolism; dephosphorylation; phosphatidic acid biosynthetic process; digestion;
	Sources:Amigo / QuickGO
Orthologs
	248
	11648
	ENSG00000163295
	ENSMUSG00000036500
	P09923
	P24822
	NM_001631
	NM_007432
	NP_001622
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Alkaline phosphatase, intestinal also known as ALPI is a type of alkaline phosphatase that in humans is encoded by the ALPI gene.^[5]^[6]

Intestinal alkaline phosphatase is an endogenous protein that plays an essential function in the maintenance of gut homeostasis. The protein is responsible for detoxifying bacterial toxins, dephosphorylating phosphorylated nucleotides, regulating lipid absorption in the intestine, and regulating the microbiome in the intestine.^[7] In addition to these functions, intestinal alkaline phosphatase can also modulate bicarbonate secretion and can modulate the pH of the duodenum.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163295 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036500 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Berger J, Garattini E, Hua JC, Udenfriend S (February 1987). "Cloning and sequencing of human intestinal alkaline phosphatase cDNA". Proceedings of the National Academy of Sciences of the United States of America. 84 (3): 695–698. Bibcode:1987PNAS...84..695B. doi:10.1073/pnas.84.3.695. PMC 304282. PMID 3468508.
^ Henthorn PS, Raducha M, Edwards YH, Weiss MJ, Slaughter C, Lafferty MA, Harris H (March 1987). "Nucleotide and amino acid sequences of human intestinal alkaline phosphatase: close homology to placental alkaline phosphatase". Proceedings of the National Academy of Sciences of the United States of America. 84 (5): 1234–1238. Bibcode:1987PNAS...84.1234H. doi:10.1073/pnas.84.5.1234. PMC 304401. PMID 3469665.
^ Fawley J, Gourlay DM (May 2016). "Intestinal alkaline phosphatase: a summary of its role in clinical disease". The Journal of Surgical Research. 202 (1): 225–234. doi:10.1016/j.jss.2015.12.008. PMC 4834149. PMID 27083970.
^ Lallès JP (June 2010). "Intestinal alkaline phosphatase: multiple biological roles in maintenance of intestinal homeostasis and modulation by diet". Nutrition Reviews. 68 (6): 323–332. doi:10.1111/j.1753-4887.2010.00292.x. PMID 20536777.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163295 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036500 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3468508-5] Berger J, Garattini E, Hua JC, Udenfriend S (February 1987). "Cloning and sequencing of human intestinal alkaline phosphatase cDNA". Proceedings of the National Academy of Sciences of the United States of America. 84 (3): 695–698. Bibcode:1987PNAS...84..695B. doi:10.1073/pnas.84.3.695. PMC 304282. PMID 3468508.

[pmid3469665-6] Henthorn PS, Raducha M, Edwards YH, Weiss MJ, Slaughter C, Lafferty MA, Harris H (March 1987). "Nucleotide and amino acid sequences of human intestinal alkaline phosphatase: close homology to placental alkaline phosphatase". Proceedings of the National Academy of Sciences of the United States of America. 84 (5): 1234–1238. Bibcode:1987PNAS...84.1234H. doi:10.1073/pnas.84.5.1234. PMC 304401. PMID 3469665.

[7] Fawley J, Gourlay DM (May 2016). "Intestinal alkaline phosphatase: a summary of its role in clinical disease". The Journal of Surgical Research. 202 (1): 225–234. doi:10.1016/j.jss.2015.12.008. PMC 4834149. PMID 27083970.

[8] Lallès JP (June 2010). "Intestinal alkaline phosphatase: multiple biological roles in maintenance of intestinal homeostasis and modulation by diet". Nutrition Reviews. 68 (6): 323–332. doi:10.1111/j.1753-4887.2010.00292.x. PMID 20536777.

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