ANAPC11

ANAPC11
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2MT5, 4R2Y, 4UI9, 5A31, 5G04, 5JG6, 5G05
Identifiers
Aliases	ANAPC11, APC11, Apc11p, HSPC214, anaphase promoting complex subunit 11
External IDs	OMIM: 614534; MGI: 1913406; HomoloGene: 41136; GeneCards: ANAPC11; OMA:ANAPC11 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	81,900,991 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	120,499,024 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; apex of heart; ; temporal lobe; ; muscle of thigh; ; amygdala; ; left ventricle; ; gastrocnemius muscle; ; right auricle; ; substantia nigra;
	Top expressed in
	atrium; ; yolk sac; ; embryo; ; morula; ; efferent ductule; ; medial ganglionic eminence; ; optic nerve; ; epiblast; ; Ileal epithelium; ; human fetus;
	More reference expression data
	n/a
Gene ontology
Molecular function	cullin family protein binding; ubiquitin protein ligase activity; metal ion binding; ubiquitin-protein transferase activity; ubiquitin-ubiquitin ligase activity;
Cellular component	cytoplasm; cytosol; anaphase-promoting complex; nucleus; nucleoplasm; nucleolus; cullin-RING ubiquitin ligase complex;
Biological process	protein K11-linked ubiquitination; cell division; protein ubiquitination; cell cycle; anaphase-promoting complex-dependent catabolic process; mitotic cell cycle; positive regulation of mitotic metaphase/anaphase transition; ubiquitin-dependent protein catabolic process; regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	51529
	66156
	ENSG00000141552
	ENSMUSG00000025135
	Q9NYG5
	Q9CPX9
NM_016476; NM_001002244; NM_001002245; NM_001002246; NM_001002247;
	NM_001002248; NM_001002249; NM_001289414; NM_001289415; NM_001289416; NM_001289417; NM_001289418; NM_001289419; NM_001289420
	NM_001038230; NM_025389
NP_001002244; NP_001002245; NP_001002246; NP_001002247; NP_001002248;
	NP_001002249; NP_001276343; NP_001276344; NP_001276345; NP_001276346; NP_001276349; NP_057560
	NP_001033319; NP_079665
	Wikidata
View/Edit Human	View/Edit Mouse

Anaphase-promoting complex subunit 11 is an enzyme that in humans is encoded by the ANAPC11 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000141552 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025135 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (Sep 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proc Natl Acad Sci U S A. 97 (16): 8973–8. Bibcode:2000PNAS...97.8973G. doi:10.1073/pnas.97.16.8973. PMC 16806. PMID 10922056.
^ "Entrez Gene: ANAPC11 APC11 anaphase promoting complex subunit 11 homolog (yeast)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000141552 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025135 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10922056-5] Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (Sep 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proc Natl Acad Sci U S A. 97 (16): 8973–8. Bibcode:2000PNAS...97.8973G. doi:10.1073/pnas.97.16.8973. PMC 16806. PMID 10922056.

[entrez-6] "Entrez Gene: ANAPC11 APC11 anaphase promoting complex subunit 11 homolog (yeast)".

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