AP2A2

AP2A2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1B9K, 1KY6, 1KY7, 1KYD, 1KYF, 1KYU, 1QTP, 1QTS, 1W80, 2JKR, 2JKT, 2VJ0, 3HS8
Identifiers
Aliases	AP2A2, ADTAB, CLAPA2, HIP-9, HIP9, HYPJ, adaptor related protein complex 2 alpha 2 subunit, adaptor related protein complex 2 subunit alpha 2
External IDs	OMIM: 607242; MGI: 101920; HomoloGene: 5335; GeneCards: AP2A2; OMA:AP2A2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	1,012,245 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	141,212,924 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; spleen; ; superior frontal gyrus; ; sural nerve; ; right frontal lobe; ; subcutaneous adipose tissue; ; prefrontal cortex; ; canal of the cervix; ; pituitary gland; ; ganglionic eminence;
	Top expressed in
	perirhinal cortex; ; entorhinal cortex; ; neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; stroma of bone marrow; ; CA3 field; ; medullary collecting duct; ; superior frontal gyrus; ; primary visual cortex; ; cerebellar cortex;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	clathrin adaptor activity; protein binding; protein kinase binding; lipid binding; protein domain specific binding; disordered domain specific binding; molecular function;
Cellular component	endocytic vesicle membrane; cytosol; clathrin-coated endocytic vesicle membrane; membrane; plasma membrane; endolysosome membrane; membrane coat; clathrin-coated pit; AP-2 adaptor complex; clathrin adaptor complex; secretory granule membrane; cytoplasmic vesicle; ficolin-1-rich granule membrane; clathrin-coated endocytic vesicle;
Biological process	endocytosis; antigen processing and presentation of exogenous peptide antigen via MHC class II; ephrin receptor signaling pathway; mitigation of host defenses by virus; clathrin-dependent endocytosis; protein transport; intracellular protein transport; vesicle-mediated transport; microtubule-based movement; Wnt signaling pathway, planar cell polarity pathway; neutrophil degranulation; membrane organization; low-density lipoprotein particle receptor catabolic process; low-density lipoprotein particle clearance; transport;
	Sources:Amigo / QuickGO
Orthologs
	161
	11772
	ENSG00000281385; ENSG00000280759; ENSG00000183020
	ENSMUSG00000002957
	O94973
	P17427
	NM_001242837; NM_012305
	NM_007459; NM_001357068
	NP_001229766; NP_036437
	NP_031485; NP_001343997
	Wikidata
View/Edit Human	View/Edit Mouse

AP-2 complex subunit alpha-2 is a protein that in humans is encoded by the AP2A2 gene.^[5]^[6]^[7]

^ ^a ^b ^c ENSG00000280759, ENSG00000183020 GRCh38: Ensembl release 89: ENSG00000281385, ENSG00000280759, ENSG00000183020 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002957 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Faber PW, Barnes GT, Srinidhi J, Chen J, Gusella JF, MacDonald ME (Sep 1998). "Huntingtin interacts with a family of WW domain proteins". Human Molecular Genetics. 7 (9): 1463–74. doi:10.1093/hmg/7.9.1463. PMID 9700202.
^ Robinson MS (Mar 1989). "Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins)". The Journal of Cell Biology. 108 (3): 833–42. doi:10.1083/jcb.108.3.833. PMC 2115374. PMID 2564002.
^ "Entrez Gene: AP2A2 adaptor-related protein complex 2, alpha 2 subunit".

[refGRCh38Ensembl-1] ENSG00000280759, ENSG00000183020 GRCh38: Ensembl release 89: ENSG00000281385, ENSG00000280759, ENSG00000183020 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002957 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9700202-5] Faber PW, Barnes GT, Srinidhi J, Chen J, Gusella JF, MacDonald ME (Sep 1998). "Huntingtin interacts with a family of WW domain proteins". Human Molecular Genetics. 7 (9): 1463–74. doi:10.1093/hmg/7.9.1463. PMID 9700202.

[pmid2564002-6] Robinson MS (Mar 1989). "Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins)". The Journal of Cell Biology. 108 (3): 833–42. doi:10.1083/jcb.108.3.833. PMC 2115374. PMID 2564002.

[entrez-7] "Entrez Gene: AP2A2 adaptor-related protein complex 2, alpha 2 subunit".

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