AP2S1

AP2S1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JKR, 2JKT, 2VGL, 2XA7, 4UQI, 4NEE
Identifiers
Aliases	AP2S1, AP17, CLAPS2, FBH3, FBHOk, HHC3, adaptor related protein complex 2 sigma 1 subunit, adaptor related protein complex 2 subunit sigma 1
External IDs	OMIM: 602242; MGI: 2141861; HomoloGene: 3001; GeneCards: AP2S1; OMA:AP2S1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	46,850,846 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	16,483,219 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; right adrenal gland; ; right frontal lobe; ; mucosa of transverse colon; ; human penis; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; prefrontal cortex; ; cingulate gyrus;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; superior frontal gyrus; ; granulocyte; ; facial motor nucleus; ; neural tube; ; ventricular zone; ; yolk sac; ; lip; ; stroma of bone marrow;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transporter activity; clathrin adaptor activity; protein binding;
Cellular component	endocytic vesicle membrane; cytosol; clathrin-coated endocytic vesicle membrane; membrane; plasma membrane; endolysosome membrane; membrane coat; clathrin-coated pit; AP-2 adaptor complex; clathrin-coated endocytic vesicle; intracellular membrane-bounded organelle;
Biological process	regulation of endocytosis; endocytosis; antigen processing and presentation of exogenous peptide antigen via MHC class II; ephrin receptor signaling pathway; mitigation of host defenses by virus; clathrin-dependent endocytosis; clathrin coat assembly; protein transport; intracellular protein transport; vesicle-mediated transport; microtubule-based movement; Wnt signaling pathway, planar cell polarity pathway; membrane organization; low-density lipoprotein particle receptor catabolic process; low-density lipoprotein particle clearance; transport;
	Sources:Amigo / QuickGO
Orthologs
	1175
	232910
	ENSG00000042753
	ENSMUSG00000008036
	P53680
	P62743
	NM_001301076; NM_001301078; NM_001301081; NM_004069; NM_021575
	NM_198613
	NP_001288005; NP_001288007; NP_001288010; NP_004060; NP_067586
	NP_941015
	Wikidata
View/Edit Human	View/Edit Mouse

AP-2 complex subunit sigma is a protein that in humans is encoded by the AP2S1 gene.^[5]^[6]^[7]

One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing has been observed in this gene and results in two known transcripts.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000042753 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000008036 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Winterpacht A, Endele S, Enklaar T, Fuhry M, Zabel B (Mar 1997). "Human CLAPS2 encoding AP17, a small chain of the clathrin-associated protein complex: cDNA cloning and chromosomal assignment to 19q13.2→q13.3". Cytogenet Cell Genet. 75 (2–3): 132–5. doi:10.1159/000134463. PMID 9040778.
^ Holzmann K, Poltl A, Sauermann G (Nov 1998). "A novel spliced transcript of human CLAPS2 encoding a protein alternative to clathrin adaptor protein AP17". Gene. 220 (1–2): 39–44. doi:10.1016/S0378-1119(98)00406-5. PMID 9767099.
^ ^a ^b "Entrez Gene: AP2S1 adaptor-related protein complex 2, sigma 1 subunit".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000042753 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000008036 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9040778-5] Winterpacht A, Endele S, Enklaar T, Fuhry M, Zabel B (Mar 1997). "Human CLAPS2 encoding AP17, a small chain of the clathrin-associated protein complex: cDNA cloning and chromosomal assignment to 19q13.2→q13.3". Cytogenet Cell Genet. 75 (2–3): 132–5. doi:10.1159/000134463. PMID 9040778.

[pmid9767099-6] Holzmann K, Poltl A, Sauermann G (Nov 1998). "A novel spliced transcript of human CLAPS2 encoding a protein alternative to clathrin adaptor protein AP17". Gene. 220 (1–2): 39–44. doi:10.1016/S0378-1119(98)00406-5. PMID 9767099.

[entrez-7] "Entrez Gene: AP2S1 adaptor-related protein complex 2, sigma 1 subunit".

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