APAF1

APAF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1C15, 1CWW, 1CY5, 1Z6T, 2P1H, 2YGS, 3J2T, 3YGS, 4RHW, 3JBT
Identifiers
Aliases	APAF1, APAF-1, CED4, apoptotic peptidase activating factor 1
External IDs	OMIM: 602233; MGI: 1306796; HomoloGene: 7626; GeneCards: APAF1; OMA:APAF1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	98,735,433 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	91,082,770 bp
RNA expression pattern
	Top expressed in
	monocyte; ; ventricular zone; ; blood; ; bone marrow cells; ; ganglionic eminence; ; epithelium of colon; ; granulocyte; ; Achilles tendon; ; trabecular bone; ; testicle;
	Top expressed in
	granulocyte; ; dermis; ; migratory enteric neural crest cell; ; ureter; ; jejunum; ; vas deferens; ; otic vesicle; ; stroma of bone marrow; ; gastrula; ; ileum;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	heat shock protein binding; ADP binding; protein binding; identical protein binding; ATP binding; nucleotide binding; cysteine-type endopeptidase activator activity involved in apoptotic process;
Cellular component	cytoplasm; cytosol; extracellular exosome; nucleus; apoptosome; extracellular region; secretory granule lumen; ficolin-1-rich granule lumen; protein-containing complex;
Biological process	cellular response to transforming growth factor beta stimulus; neuron apoptotic process; regulation of apoptotic process; cell differentiation; response to hypoxia; response to nutrient; response to G1 DNA damage checkpoint signaling; human ageing; positive regulation of apoptotic signaling pathway; glial cell apoptotic process; nervous system development; multicellular organism development; cardiac muscle cell apoptotic process; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; neural tube closure; brain development; positive regulation of apoptotic process; apoptotic signaling pathway; forebrain development; regulation of apoptotic DNA fragmentation; protein homooligomerization; activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; apoptotic process; neutrophil degranulation; negative regulation of G0 to G1 transition; kidney development;
	Sources:Amigo / QuickGO
Orthologs
	317
	11783
	ENSG00000120868
	ENSMUSG00000019979
	O14727
	O88879
	NM_001160; NM_013229; NM_181861; NM_181868; NM_181869
	NM_001042558; NM_001282947; NM_009684
	NP_001151; NP_037361; NP_863651; NP_863658; NP_863659
	NP_001036023; NP_001269876; NP_033814
	Wikidata
View/Edit Human	View/Edit Mouse

Apoptotic protease activating factor 1, also known as APAF1, is a human homolog of C. elegans CED-4 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000120868 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019979 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cite error: The named reference entrez was invoked but never defined (see the help page).
^ Zou H, Henzel WJ, Liu X, Lutschg A, Wang X (Aug 1997). "Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3". Cell. 90 (3): 405–13. doi:10.1016/S0092-8674(00)80501-2. PMID 9267021. S2CID 18105320.
^ Kim H, Jung YK, Kwon YK, Park SH (1999). "Assignment of apoptotic protease activating factor-1 gene (APAF1) to human chromosome band 12q23 by fluorescence in situ hybridization". Cytogenetics and Cell Genetics. 87 (3–4): 252–3. doi:10.1159/000015436. PMID 10702682. S2CID 10377371.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000120868 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019979 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] Cite error: The named reference entrez was invoked but never defined (see the help page).

[pmid9267021-6] Zou H, Henzel WJ, Liu X, Lutschg A, Wang X (Aug 1997). "Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3". Cell. 90 (3): 405–13. doi:10.1016/S0092-8674(00)80501-2. PMID 9267021. S2CID 18105320.

[pmid10702682-7] Kim H, Jung YK, Kwon YK, Park SH (1999). "Assignment of apoptotic protease activating factor-1 gene (APAF1) to human chromosome band 12q23 by fluorescence in situ hybridization". Cytogenetics and Cell Genetics. 87 (3–4): 252–3. doi:10.1159/000015436. PMID 10702682. S2CID 10377371.

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