APOBEC3D

APOBEC3D
Identifiers
Aliases	APOBEC3D, A3D, APOBEC3DE, APOBEC3E, ARP6, apolipoprotein B mRNA editing enzyme catalytic subunit 3D, A3DE
External IDs	OMIM: 609900; HomoloGene: 122788; GeneCards: APOBEC3D; OMA:APOBEC3D - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	39,033,277 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; lymph node; ; spleen; ; bone marrow cells; ; blood; ; appendix; ; right uterine tube; ; monocyte; ; gallbladder; ; rectum;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines; zinc ion binding; catalytic activity; hydrolase activity; metal ion binding; RNA binding; cytidine deaminase activity;
Cellular component	cytoplasm; P-body; nucleus;
Biological process	negative regulation of transposition; innate immune response; defense response to virus; DNA cytosine deamination; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; immune system process; cytidine deamination; cytidine to uridine editing; DNA demethylation;
	Sources:Amigo / QuickGO
Orthologs
	140564
	n/a
	ENSG00000243811
	n/a
	B2CML4
	n/a
	NM_152426; NM_001363781
	n/a
	NP_689639; NP_001350710
	n/a
	Wikidata
View/Edit Human

Probable DNA dC->dU-editing enzyme APOBEC-3D is a protein that in humans is encoded by the APOBEC3D gene.^[3]^[4]

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1 and inhibit retroviruses, such as HIV, by deaminating cytosine residues in nascent retroviral cDNA.^[4]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000243811 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jarmuz A, Chester A, Bayliss J, Gisbourne J, Dunham I, Scott J, Navaratnam N (Feb 2002). "An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22". Genomics. 79 (3): 285–96. doi:10.1006/geno.2002.6718. PMID 11863358.
^ ^a ^b "Entrez Gene: APOBEC3D apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D (putative)".