ARG1 (gene)

ARG1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WVA, 1WVB, 2AEB, 2PHA, 2PHO, 2PLL, 2ZAV, 3DJ8, 3E6K, 3E6V, 3F80, 3GMZ, 3GN0, 3KV2, 3LP4, 3LP7, 3MFV, 3MFW, 3MJL, 3SJT, 3SKK, 3TF3, 3TH7, 3THE, 3THH, 3THJ, 4FCI, 4FCK, 4GSM, 4GSV, 4GSZ, 4GWC, 4GWD, 4HWW, 4HXQ, 4IE1
Identifiers
Aliases	ARG1, arginase 1
External IDs	OMIM: 608313; MGI: 88070; HomoloGene: 29; GeneCards: ARG1; OMA:ARG1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	131,584,332 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	24,803,382 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; human penis; ; skin of arm; ; trabecular bone; ; bone marrow; ; vulva; ; bone marrow cells; ; skin of leg; ; skin of hip; ; skin of abdomen;
	Top expressed in
	left lobe of liver; ; gallbladder; ; cervix; ; parotid gland; ; superior surface of tongue; ; esophagus; ; primitive streak; ; somite; ; corneal stroma; ; lacrimal gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	arginase activity; manganese ion binding; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines; metal ion binding; hydrolase activity; protein binding;
Cellular component	cytoplasm; cytosol; mitochondrial outer membrane; soma; neuron projection; extracellular exosome; nucleus; extracellular region; azurophil granule lumen; specific granule lumen; extracellular space;
Biological process	cellular response to interleukin-4; cellular response to transforming growth factor beta stimulus; response to selenium ion; response to amino acid; response to cadmium ion; positive regulation of endothelial cell proliferation; maternal process involved in female pregnancy; lung development; urea cycle; female pregnancy; response to steroid hormone; cellular response to glucagon stimulus; human ageing; response to peptide hormone; response to zinc ion; arginine catabolic process; arginine metabolic process; response to vitamin E; protein homotrimerization; cellular response to dexamethasone stimulus; response to vitamin A; arginine catabolic process to ornithine; response to lipopolysaccharide; response to manganese ion; response to wounding; response to axon injury; collagen biosynthetic process; response to amine; liver development; response to methylmercury; cellular response to lipopolysaccharide; response to herbicide; cellular response to hydrogen peroxide; mammary gland involution; neutrophil degranulation; negative regulation of T cell proliferation; defense response to protozoan; negative regulation of activated T cell proliferation; negative regulation of interferon-gamma-mediated signaling pathway; positive regulation of neutrophil mediated killing of fungus; negative regulation of T-helper 2 cell cytokine production; adaptive immune response; immune system process; innate immune response;
	Sources:Amigo / QuickGO
Orthologs
	383
	11846
	ENSG00000118520
	ENSMUSG00000019987
	P05089
	Q61176
	NM_000045; NM_001244438; NM_001369020
	NM_007482
	NP_000036; NP_001231367; NP_001355949
	NP_031508
	Wikidata
View/Edit Human	View/Edit Mouse

The human ARG1 gene encodes the protein arginase.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000118520 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019987 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Arginase, liver".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000118520 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019987 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Arginase, liver".

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