ARNT2

ARNT2
Identifiers
Aliases	ARNT2, WEDAS, bHLHe1, aryl hydrocarbon receptor nuclear translocator 2
External IDs	OMIM: 606036; MGI: 107188; HomoloGene: 7230; GeneCards: ARNT2; OMA:ARNT2 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	80,597,933 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	84,059,384 bp
RNA expression pattern
	Top expressed in
	external globus pallidus; ; middle temporal gyrus; ; frontal pole; ; middle frontal gyrus; ; Brodmann area 10; ; entorhinal cortex; ; optic nerve; ; superior vestibular nucleus; ; parietal lobe; ; ventral tegmental area;
	Top expressed in
	subiculum; ; superior frontal gyrus; ; paraventricular nucleus of hypothalamus; ; globus pallidus; ; nucleus accumbens; ; dorsal tegmental nucleus; ; dorsomedial hypothalamic nucleus; ; ganglionic eminence; ; ventral tegmental area; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein dimerization activity; DNA-binding transcription factor activity; aryl hydrocarbon receptor binding; DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; protein binding; protein heterodimerization activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; transcription regulator complex; nucleus; nucleoplasm;
Biological process	response to estradiol; response to hypoxia; regulation of transcription, DNA-templated; negative regulation of apoptotic process; in utero embryonic development; transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of transcription, DNA-templated; central nervous system development; brain development; positive regulation of cell population proliferation; xenobiotic metabolic process; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	9915
	11864
	ENSG00000172379
	ENSMUSG00000015709
	Q9HBZ2
	Q61324
	NM_014862
	NM_007488
	NP_055677; NP_055677.3
	NP_031514
	Wikidata
View/Edit Human	View/Edit Mouse

Aryl hydrocarbon receptor nuclear translocator 2 is a protein that in humans is encoded by the ARNT2 gene.^[5]^[6]

This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting addition roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172379 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015709 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wines ME, Lee L, Katari MS, Zhang L, DeRossi C, Shi Y, Perkins S, Feldman M, McCombie WR, Holdener BC (Mar 2001). "Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis". Genomics. 72 (1): 88–98. doi:10.1006/geno.2000.6466. PMID 11247670.
^ ^a ^b "Entrez Gene: ARNT2 aryl-hydrocarbon receptor nuclear translocator 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000172379 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015709 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11247670-5] Wines ME, Lee L, Katari MS, Zhang L, DeRossi C, Shi Y, Perkins S, Feldman M, McCombie WR, Holdener BC (Mar 2001). "Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis". Genomics. 72 (1): 88–98. doi:10.1006/geno.2000.6466. PMID 11247670.

[entrez-6] "Entrez Gene: ARNT2 aryl-hydrocarbon receptor nuclear translocator 2".

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