ASCC3L1

SNRNP200
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2Q0Z, 4F91, 4F92, 4F93, 4KIT, 3JCR
Identifiers
Aliases	SNRNP200, ASCC3L1, BRR2, HELIC2, RP33, U5-200KD, small nuclear ribonucleoprotein U5 subunit 200
External IDs	OMIM: 601664; MGI: 2444401; HomoloGene: 5859; GeneCards: SNRNP200; OMA:SNRNP200 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	96,321,271 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	127,082,371 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; embryo; ; epithelium of nasopharynx; ; ganglionic eminence; ; nasal epithelium; ; urethra; ; parotid gland; ; pylorus; ; nipple; ; tibia;
	Top expressed in
	hand; ; otic vesicle; ; mandibular prominence; ; maxillary prominence; ; primitive streak; ; condyle; ; abdominal wall; ; Paneth cell; ; Gonadal ridge; ; otolith organ;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; helicase activity; protein binding; identical protein binding; nucleic acid binding; hydrolase activity; ATP binding; RNA binding;
Cellular component	catalytic step 2 spliceosome; membrane; U5 snRNP; nucleoplasm; spliceosomal complex; nucleus; U4/U6 x U5 tri-snRNP complex; post-mRNA release spliceosomal complex;
Biological process	mRNA splicing, via spliceosome; mRNA processing; osteoblast differentiation; cis assembly of pre-catalytic spliceosome; RNA splicing; spliceosome conformational change to release U4 (or U4atac) and U1 (or U11);
	Sources:Amigo / QuickGO
Orthologs
	23020
	320632
	ENSG00000144028
	ENSMUSG00000003660
	O75643
	Q6P4T2
	NM_014014
	NM_177214
	NP_054733
	NP_796188
	Wikidata
View/Edit Human	View/Edit Mouse

U5 small nuclear ribonucleoprotein 200 kDa helicase is an enzyme that in humans is encoded by the SNRNP200 gene.^[5]^[6]^[7]^[8]^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000144028 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003660 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
^ Lauber J, Fabrizio P, Teigelkamp S, Lane WS, Hartmann E, Luhrmann R (Oct 1996). "The HeLa 200 kDa U5 snRNP-specific protein and its homologue in Saccharomyces cerevisiae are members of the DEXH-box protein family of putative RNA helicases". EMBO J. 15 (15): 4001–15. doi:10.1002/j.1460-2075.1996.tb00774.x. PMC 452120. PMID 8670905.
^ Achsel T, Ahrens K, Brahms H, Teigelkamp S, Luhrmann R (Nov 1998). "The Human U5-220kD Protein (hPrp8) Forms a Stable RNA-Free Complex with Several U5-Specific Proteins, Including an RNA Unwindase, a Homologue of Ribosomal Elongation Factor EF-2, and a Novel WD-40 Protein". Mol Cell Biol. 18 (11): 6756–66. doi:10.1128/mcb.18.11.6756. PMC 109259. PMID 9774689.
^ Laggerbauer B, Achsel T, Luhrmann R (May 1998). "The human U5-200kD DEXH-box protein unwinds U4/U6 RNA duplices in vitro". Proc Natl Acad Sci U S A. 95 (8): 4188–92. Bibcode:1998PNAS...95.4188L. doi:10.1073/pnas.95.8.4188. PMC 22463. PMID 9539711.
^ "Entrez Gene: ASCC3L1 activating signal cointegrator 1 complex subunit 3-like 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000144028 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000003660 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9872452-5] Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.

[pmid8670905-6] Lauber J, Fabrizio P, Teigelkamp S, Lane WS, Hartmann E, Luhrmann R (Oct 1996). "The HeLa 200 kDa U5 snRNP-specific protein and its homologue in Saccharomyces cerevisiae are members of the DEXH-box protein family of putative RNA helicases". EMBO J. 15 (15): 4001–15. doi:10.1002/j.1460-2075.1996.tb00774.x. PMC 452120. PMID 8670905.

[pmid9774689-7] Achsel T, Ahrens K, Brahms H, Teigelkamp S, Luhrmann R (Nov 1998). "The Human U5-220kD Protein (hPrp8) Forms a Stable RNA-Free Complex with Several U5-Specific Proteins, Including an RNA Unwindase, a Homologue of Ribosomal Elongation Factor EF-2, and a Novel WD-40 Protein". Mol Cell Biol. 18 (11): 6756–66. doi:10.1128/mcb.18.11.6756. PMC 109259. PMID 9774689.

[pmid9539711-8] Laggerbauer B, Achsel T, Luhrmann R (May 1998). "The human U5-200kD DEXH-box protein unwinds U4/U6 RNA duplices in vitro". Proc Natl Acad Sci U S A. 95 (8): 4188–92. Bibcode:1998PNAS...95.4188L. doi:10.1073/pnas.95.8.4188. PMC 22463. PMID 9539711.

[entrez-9] "Entrez Gene: ASCC3L1 activating signal cointegrator 1 complex subunit 3-like 1".

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