ASIC4

ASIC4
Identifiers
Aliases	ASIC4, ACCN4, BNAC4, acid sensing ion channel subunit family member 4
External IDs	OMIM: 606715; MGI: 2652846; HomoloGene: 11166; GeneCards: ASIC4; OMA:ASIC4 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	219,538,772 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	75,450,987 bp
RNA expression pattern
	Top expressed in
	pituitary gland; ; anterior pituitary; ; right hemisphere of cerebellum; ; amygdala; ; cingulate gyrus; ; anterior cingulate cortex; ; lateral nuclear group of thalamus; ; right frontal lobe; ; hypothalamus; ; substantia nigra;
	Top expressed in
	neural layer of retina; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; olfactory tubercle; ; embryo; ; superior colliculus; ; nucleus accumbens; ; central gray substance of midbrain; ; lumbar subsegment of spinal cord;
	More reference expression data
	n/a
Gene ontology
Molecular function	ion channel activity; sodium ion transmembrane transporter activity; sodium channel activity;
Cellular component	integral component of membrane; integral component of plasma membrane; membrane;
Biological process	ion transport; sodium ion transport; ion transmembrane transport; sodium ion transmembrane transport; behavioral fear response;
	Sources:Amigo / QuickGO
Orthologs
	55515
	241118
	ENSG00000072182
	ENSMUSG00000033007
	Q96FT7
	Q7TNS7
	NM_018674; NM_182847
	NM_183022
	NP_061144; NP_878267
	NP_898843
	Wikidata
View/Edit Human	View/Edit Mouse

Acid-sensing ion channel 4 (ASIC4) also known as amiloride-sensitive cation channel 4 (ACCN4) is a protein that in humans is encoded by the ASIC4 gene. The ASIC4 gene is one of the five paralogous genes that encode proteins that form trimeric acid-sensing ion channels (ASICs) in mammals.^[5] The cDNA of this gene was first cloned in 2000.^[6]^[7] The ASIC genes have splicing variants that encode different proteins that are called isoforms.

These genes are mainly expressed in the central and peripheral nervous system.

ASICs can form both homotrimeric (meaning composed of three identical subunits) and heterotrimeric channels.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000072182 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033007 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hanukoglu I (2017). "ASIC and ENaC type sodium channels: Conformational states and the structures of the ion selectivity filters". FEBS Journal. 284 (4): 525–545. doi:10.1111/febs.13840. PMID 27580245. S2CID 24402104.
^ Gründer S, Geissler HS, Bässler EL, Ruppersberg JP (2000). "A new member of acid-sensing ion channels from pituitary gland". NeuroReport. 11 (8): 1607–11. doi:10.1097/00001756-200006050-00003. PMID 10852210. S2CID 46420660.
^ Gründer S, Geisler HS, Rainier S, Fink JK (2001). "Acid-sensing ion channel (ASIC) 4 gene: physical mapping, genomic organisation, and evaluation as a candidate for paroxysmal dystonia". Eur. J. Hum. Genet. 9 (9): 672–6. doi:10.1038/sj.ejhg.5200699. PMID 11571555.
^ Babinski K, Catarsi S, Biagini G, Séguéla P (Sep 2000). "Mammalian ASIC2a and ASIC3 subunits co-assemble into heteromeric proton-gated channels sensitive to Gd3+". The Journal of Biological Chemistry. 275 (37): 28519–25. doi:10.1074/jbc.M004114200. hdl:11380/304669. PMID 10842183.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000072182 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033007 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[2017-Hanukoglu-5] Hanukoglu I (2017). "ASIC and ENaC type sodium channels: Conformational states and the structures of the ion selectivity filters". FEBS Journal. 284 (4): 525–545. doi:10.1111/febs.13840. PMID 27580245. S2CID 24402104.

[6] Gründer S, Geissler HS, Bässler EL, Ruppersberg JP (2000). "A new member of acid-sensing ion channels from pituitary gland". NeuroReport. 11 (8): 1607–11. doi:10.1097/00001756-200006050-00003. PMID 10852210. S2CID 46420660.

[7] Gründer S, Geisler HS, Rainier S, Fink JK (2001). "Acid-sensing ion channel (ASIC) 4 gene: physical mapping, genomic organisation, and evaluation as a candidate for paroxysmal dystonia". Eur. J. Hum. Genet. 9 (9): 672–6. doi:10.1038/sj.ejhg.5200699. PMID 11571555.

[8] Babinski K, Catarsi S, Biagini G, Séguéla P (Sep 2000). "Mammalian ASIC2a and ASIC3 subunits co-assemble into heteromeric proton-gated channels sensitive to Gd3+". The Journal of Biological Chemistry. 275 (37): 28519–25. doi:10.1074/jbc.M004114200. hdl:11380/304669. PMID 10842183.

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