ATOH1

ATOH1
Identifiers
Aliases	ATOH1, ATH1, HATH1, MATH-1, bHLHa14, atonal bHLH transcription factor 1
External IDs	OMIM: 601461; MGI: 104654; HomoloGene: 31297; GeneCards: ATOH1; OMA:ATOH1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	93,830,964 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	64,708,229 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; rectum; ; mucosa of sigmoid colon; ; duodenum; ; jejunal mucosa; ; epithelium of colon; ; appendix; ; muscle tissue; ; smooth muscle tissue; ; muscle layer of sigmoid colon;
	Top expressed in
	rhombic lip; ; crypt of lieberkuhn of small intestine; ; left colon; ; Paneth cell; ; vestibular sensory epithelium; ; intestinal villus; ; jejunum; ; ileum; ; urethra; ; male urethra;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; protein dimerization activity; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; chromatin DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	Notch signaling pathway; regulation of neuron differentiation; auditory receptor cell fate determination; cell differentiation; positive regulation of inner ear auditory receptor cell differentiation; regulation of transcription, DNA-templated; positive regulation of inner ear receptor cell differentiation; negative regulation of apoptotic process; neuron migration; auditory receptor cell fate specification; transcription, DNA-templated; nervous system development; axon guidance; multicellular organism development; central nervous system development; brain development; inner ear auditory receptor cell differentiation; inner ear morphogenesis; positive regulation of neuron differentiation; neuron differentiation; cerebral cortex development; inner ear development; positive regulation of transcription by RNA polymerase II; transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	474
	11921
	ENSG00000172238
	ENSMUSG00000073043
	Q92858
	P48985
	NM_005172
	NM_007500
	NP_005163
	NP_031526
	Wikidata
View/Edit Human	View/Edit Mouse

Protein atonal homolog 1 is a protein that in humans is encoded by the ATOH1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172238 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000073043 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ben-Arie N, McCall AE, Berkman S, Eichele G, Bellen HJ, Zoghbi HY (September 1996). "Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis". Human Molecular Genetics. 5 (9): 1207–16. doi:10.1093/hmg/5.9.1207. hdl:11858/00-001M-0000-0010-50D1-1. PMID 8872459.
^ "Entrez Gene: ATOH1 atonal homolog 1 (Drosophila)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000172238 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000073043 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8872459-5] Ben-Arie N, McCall AE, Berkman S, Eichele G, Bellen HJ, Zoghbi HY (September 1996). "Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis". Human Molecular Genetics. 5 (9): 1207–16. doi:10.1093/hmg/5.9.1207. hdl:11858/00-001M-0000-0010-50D1-1. PMID 8872459.

[entrez-6] "Entrez Gene: ATOH1 atonal homolog 1 (Drosophila)".

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