 Multidrug ABC transporter SAV1866, closed state | |||||||||||
| Identifiers | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Symbol | ABC_tran | ||||||||||
| Pfam | PF00005 | ||||||||||
| InterPro | IPR003439 | ||||||||||
| PROSITE | PDOC00185 | ||||||||||
| SCOP2 | 1b0u / SCOPe / SUPFAM | ||||||||||
| TCDB | 3.A.1 | ||||||||||
| OPM superfamily | 17 | ||||||||||
| OPM protein | 2hyd | ||||||||||
| CDD | cd00267 | ||||||||||
| |||||||||||
In molecular biology, ATP-binding domain of ABC transporters is a water-soluble domain of transmembrane ABC transporters.
ABC transporters belong to the ATP-Binding Cassette superfamily, which uses the hydrolysis of ATP to translocate a variety of compounds across biological membranes. ABC transporters are minimally constituted of two conserved regions: a highly conserved ATP binding cassette (ABC) and a less conserved transmembrane domain (TMD). These regions can be found on the same protein or on two different ones. Most ABC transporters function as a dimer and therefore are constituted of four domains, two ABC modules and two TMDs.