ATP1A2

ATP1A2
Identifiers
Aliases	ATP1A2, FHM2, MHP2, ATPase Na+/K+ transporting subunit alpha 2, DEE98, FARIMPD
External IDs	OMIM: 182340; MGI: 88106; HomoloGene: 47947; GeneCards: ATP1A2; OMA:ATP1A2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	160,143,591 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	172,125,631 bp
RNA expression pattern
	Top expressed in
	external globus pallidus; ; trigeminal ganglion; ; superior vestibular nucleus; ; ventral tegmental area; ; endothelial cell; ; Skeletal muscle tissue of rectus abdominis; ; Skeletal muscle tissue of biceps brachii; ; paraflocculus of cerebellum; ; pars reticulata; ; subthalamic nucleus;
	Top expressed in
	ciliary body; ; iris; ; Epithelium of choroid plexus; ; substantia nigra; ; deep cerebellar nuclei; ; ankle; ; medial vestibular nucleus; ; vestibular sensory epithelium; ; sternocleidomastoid muscle; ; medial geniculate nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	steroid hormone binding; nucleotide binding; chaperone binding; potassium ion binding; sodium ion binding; P-type sodium:potassium-exchanging transporter activity; metal ion binding; ATPase-coupled cation transmembrane transporter activity; ATPase activity; protein binding; hydrolase activity; ATP binding; P-type potassium transmembrane transporter activity;
Cellular component	cytoplasm; extracellular vesicle; integral component of membrane; endosome; membrane; intercalated disc; T-tubule; myelin sheath; plasma membrane; dendritic spine; synapse; sodium:potassium-exchanging ATPase complex; caveola; neuron projection; sarcolemma;
Biological process	visual learning; cellular response to steroid hormone stimulus; regulation of muscle contraction; regulation of cardiac conduction; cardiac muscle contraction; regulation of smooth muscle contraction; sodium ion transport; regulation of the force of heart contraction; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; negative regulation of heart contraction; cellular sodium ion homeostasis; adult locomotory behavior; sodium ion export across plasma membrane; negative regulation of striated muscle contraction; cell communication by electrical coupling involved in cardiac conduction; response to nicotine; response to glycoside; ion transport; cellular potassium ion homeostasis; regulation of blood pressure; regulation of respiratory gaseous exchange by nervous system process; potassium ion transport; regulation of cardiac muscle cell contraction; ion transmembrane transport; ATP metabolic process; cellular response to mechanical stimulus; regulation of striated muscle contraction; membrane repolarization; negative regulation of calcium ion transmembrane transport; regulation of vasoconstriction; neurotransmitter uptake; negative regulation of calcium:sodium antiporter activity; locomotion; regulation of glutamate uptake involved in transmission of nerve impulse; regulation of synaptic transmission, glutamatergic; relaxation of cardiac muscle; membrane depolarization during cardiac muscle cell action potential; negative regulation of cytosolic calcium ion concentration; potassium ion import across plasma membrane; establishment or maintenance of transmembrane electrochemical gradient; transport;
	Sources:Amigo / QuickGO
Orthologs
	477
	98660
	ENSG00000018625
	ENSMUSG00000007097
	P50993
	Q6PIE5
	NM_000702
	NM_178405
	NP_000693
	NP_848492
	Wikidata
View/Edit Human	View/Edit Mouse

Sodium/potassium-transporting ATPase subunit alpha-2 is a protein which in humans is encoded by the ATP1A2 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000018625 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000007097 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "ATP1A2 - Sodium/potassium-transporting ATPase subunit alpha-2 precursor - Homo sapiens (Human) - ATP1A2 gene & protein". www.uniprot.org. Retrieved 9 April 2022.
^ "Entrez Gene: ATP1A2 ATPase, Na⁺/K⁺ transporting, alpha 2 (+) polypeptide".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000018625 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000007097 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[uniprot-5] "ATP1A2 - Sodium/potassium-transporting ATPase subunit alpha-2 precursor - Homo sapiens (Human) - ATP1A2 gene & protein". www.uniprot.org. Retrieved 9 April 2022.

[entrez-6] "Entrez Gene: ATP1A2 ATPase, Na⁺/K⁺ transporting, alpha 2 (+) polypeptide".

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