ATP2A1

ATP2A1
Identifiers
Aliases	ATP2A1, ATP2A, SERCA1, ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
External IDs	OMIM: 108730; MGI: 105058; HomoloGene: 7635; GeneCards: ATP2A1; OMA:ATP2A1 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p11.2 Start 28,878,405 bp[1] End 28,904,466 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 F3|7 69.04 cM Start 126,045,030 bp[2] End 126,062,280 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh Skeletal muscle tissue of rectus abdominis thoracic diaphragm Skeletal muscle tissue of biceps brachii vastus lateralis muscle triceps brachii muscle gastrocnemius muscle body of tongue glutes deltoid muscle Top expressed in ankle triceps brachii muscle temporal muscle sternocleidomastoid muscle digastric muscle muscle of thigh vastus lateralis muscle extensor digitorum longus muscle tibialis anterior muscle medial head of gastrocnemius muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding calcium ion binding protein homodimerization activity metal ion binding protein binding hydrolase activity ATP binding P-type calcium transporter activity ATPase activity P-type proton-exporting transporter activity Cellular component integral component of membrane endoplasmic reticulum membrane membrane I band calcium channel complex H zone sarcoplasmic reticulum platelet dense tubular network membrane endoplasmic reticulum sarcoplasmic reticulum membrane perinuclear region of cytoplasm endoplasmic reticulum-Golgi intermediate compartment mitochondrion Biological process regulation of cardiac conduction positive regulation of fast-twitch skeletal muscle fiber contraction negative regulation of striated muscle contraction calcium ion import positive regulation of endoplasmic reticulum calcium ion concentration ion transport response to endoplasmic reticulum stress maintenance of mitochondrion location ion transmembrane transport intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress regulation of striated muscle contraction apoptotic mitochondrial changes relaxation of skeletal muscle negative regulation of endoplasmic reticulum calcium ion concentration positive regulation of mitochondrial calcium ion concentration calcium ion transport calcium ion transmembrane transport cellular calcium ion homeostasis proton transmembrane transport calcium ion import into sarcoplasmic reticulum positive regulation of cardiac muscle cell contraction positive regulation of ATPase-coupled calcium transmembrane transporter activity positive regulation of calcium ion import into sarcoplasmic reticulum Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 487 11937 Ensembl ENSG00000196296 ENSMUSG00000030730 UniProt O14983 Q8R429 RefSeq (mRNA) NM_173201 NM_001286075 NM_004320 NM_007504 RefSeq (protein) NP_001273004 NP_004311 NP_775293 NP_031530 Location (UCSC) Chr 16: 28.88 – 28.9 Mb Chr 7: 126.05 – 126.06 Mb PubMed search [3] [4]
Wikidata
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Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) also known as Calcium pump 1, is an enzyme that in humans is encoded by the ATP2A1 gene.^[5][6]