ATP5F1

ATP5PB
Identifiers
Aliases	ATP5PB, PIG47, ATP synthase, H+ transporting, mitochondrial Fo complex subunit B1, ATP synthase peripheral stalk-membrane subunit b, ATP5F1
External IDs	OMIM: 603270; MGI: 1100495; HomoloGene: 1275; GeneCards: ATP5PB; OMA:ATP5PB - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.2 Start 111,448,864 bp[1] End 111,462,773 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F2.2|3 46.46 cM Start 105,850,014 bp[2] End 105,867,415 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right ventricle mucosa of sigmoid colon palpebral conjunctiva Epithelium of choroid plexus biceps brachii jejunal mucosa Skeletal muscle tissue of biceps brachii germinal epithelium oral cavity kidney tubule Top expressed in epithelium of small intestine myocardium of ventricle intercostal muscle soleus muscle atrioventricular valve medial ganglionic eminence vas deferens atrium digastric muscle endocardial cushion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding ATPase activity proton transmembrane transporter activity proton-transporting ATP synthase activity, rotational mechanism transmembrane transporter activity Cellular component nucleoplasm mitochondrion mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) mitochondrial matrix proton-transporting ATP synthase complex, coupling factor F(o) nucleus membrane myelin sheath mitochondrial proton-transporting ATP synthase complex mitochondrial inner membrane extracellular exosome Biological process substantia nigra development ion transport ATP synthesis coupled proton transport mitochondrial ATP synthesis coupled proton transport ATP biosynthetic process cristae formation transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 515 11950 Ensembl ENSG00000116459 ENSMUSG00000000563 UniProt P24539 Q9CQQ7 RefSeq (mRNA) NM_001688 NM_001002014 NM_001002015 NM_009725 NM_001304719 RefSeq (protein) NP_001679 NP_001291648 NP_033855 Location (UCSC) Chr 1: 111.45 – 111.46 Mb Chr 3: 105.85 – 105.87 Mb PubMed search [3] [4]
Wikidata
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ATP-synt_B
atp synthase b subunit dimerization domain
Identifiers
Symbol	ATP-synt_B
Pfam	PF00430
Pfam clan	CL0255
InterPro	IPR002146
SCOP2	1b9u / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

ATP synthase subunit b, mitochondrial is an enzyme that in humans is encoded by the ATP5PB gene.^[5][6]

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the b subunit of the proton channel.^[6]

The b subunits are part of the peripheral stalk that links the F1 and FO complexes together, and which acts as a stator to prevent certain subunits from rotating with the central rotary element. The peripheral stalk differs in subunit composition between mitochondrial, chloroplast and bacterial F-ATPases. In bacterial and chloroplast F-ATPases, the peripheral stalk is composed of one copy of the delta subunit (homologous to OSCP in mitochondria), and two copies of subunit b in bacteria, or one copy each of subunits b and b' in chloroplasts and photosynthetic bacteria.^[7]