ATP6V1G1

ATP6V1G1
Identifiers
Aliases	ATP6V1G1, ATP6G, ATP6G1, ATP6GL, ATP6J, Vma10, ATPase H+ transporting V1 subunit G1
External IDs	OMIM: 607296; MGI: 1913540; HomoloGene: 31272; GeneCards: ATP6V1G1; OMA:ATP6V1G1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q32 Start 114,587,706 bp[1] End 114,598,915 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 B3 Start 63,463,009 bp[2] End 63,468,987 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla pylorus cardia ganglionic eminence olfactory zone of nasal mucosa retinal pigment epithelium corpus epididymis anterior pituitary gonad oral cavity Top expressed in granulocyte yolk sac muscle of thigh right kidney spermatocyte lip ventricular zone neural layer of retina dentate gyrus of hippocampal formation granule cell blastocyst More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ATPase binding ATPase activity P-type proton-exporting transporter activity protein binding ATPase-coupled transmembrane transporter activity Cellular component cytosol plasma membrane intracellular anatomical structure lysosomal membrane vacuolar proton-transporting V-type ATPase complex extracellular exosome Biological process insulin receptor signaling pathway transferrin transport proton transmembrane transport ion transport ion transmembrane transport regulation of macroautophagy phagosome acidification cellular iron ion homeostasis cellular response to increased oxygen levels transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9550 66290 Ensembl ENSG00000136888 ENSMUSG00000039105 UniProt O75348 Q9CR51 RefSeq (mRNA) NM_004888 NM_024173 RefSeq (protein) NP_004879 NP_004879.1 NP_077135 Location (UCSC) Chr 9: 114.59 – 114.6 Mb Chr 4: 63.46 – 63.47 Mb PubMed search [3] [4]
Wikidata
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V-type proton ATPase subunit G 1 is an enzyme that in humans is encoded by the ATP6V1G1 gene.^[5][6]

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of three V1 domain G subunit proteins. Pseudogenes of this gene have been characterized.^[6]