Tyrosine-protein kinase receptor UFO is a protein that in human is encoded by the AXL gene.[5][6] The gene was initially designated as UFO, in allusion to the unidentified function of this protein.[7] However, in the years since its discovery, research into AXL's expression profile and mechanism has made it an increasingly attractive target, especially for cancer therapeutics. In recent years, AXL has emerged as a key facilitator of immune escape and drug-resistance by cancer cells, leading to aggressive and metastatic cancers.[8]
AXL is a cell surface receptor tyrosine kinase, part of the TAM family of kinases including TYRO3 and MERTK.[9]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000167601 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002602 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ O'Bryan JP, Frye RA, Cogswell PC, Neubauer A, Kitch B, Prokop C, et al. (Oct 1991). "axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase". Molecular and Cellular Biology. 11 (10): 5016–31. doi:10.1128/mcb.11.10.5016. PMC 361494. PMID 1656220.
- ^ "Entrez Gene: AXL AXL receptor tyrosine kinase".
- ^ Janssen JW, Schulz AS, Steenvoorden AC, Schmidberger M, Strehl S, Ambros PF, et al. (1991). "A novel putative tyrosine kinase receptor with oncogenic potential". Oncogene. 6 (11): 2113–20. PMID 1834974.
- ^ Davidsen KT, Haaland GS, Lie MK, Lorens JB, Engelsen AS (2017). "The Role of Axl Receptor Tyrosine Kinase in Tumor Cell Plasticity and Therapy Resistance". In Akslen L, Watnick R (eds.). Biomarkers of the Tumor Microenvironment. Cham: Springer. pp. 351–376. ISBN 978-3-319-39147-2.
- ^ Miao YR, Rankin EB, Giaccia AJ (March 2024). "Therapeutic targeting of the functionally elusive TAM receptor family". Nature Reviews. Drug Discovery. 23 (3): 201–217. doi:10.1038/s41573-023-00846-8. PMC 11335090. PMID 38092952.