 | |
| Monoclonal antibody | |
|---|---|
| Type | Fab fragment |
| Source | Chimeric (mouse/human) |
| Target | CD41 7E3 |
| Clinical data | |
| Trade names | Reopro |
| Other names | Abcixifiban,[1] c7E3 Fab |
| AHFS/Drugs.com | Monograph |
| License data | |
| Routes of administration | Intravenous (IV) |
| ATC code | |
| Legal status | |
| Legal status | |
| Identifiers | |
| CAS Number | |
| DrugBank | |
| ChemSpider |
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| UNII | |
| KEGG | |
| ChEMBL | |
| Chemical and physical data | |
| Formula | C2101H3229N551O673S15 |
| Molar mass | 47456.03 g·mol−1 |
  (what is this?) (verify) | |
Abciximab, a glycoprotein IIb/IIIa receptor antagonist manufactured by Janssen Biologics BV and distributed by Eli Lilly under the trade name ReoPro, is a platelet aggregation inhibitor mainly used during and after coronary artery procedures like angioplasty to prevent platelets from sticking together and causing thrombus (blood clot) formation within the coronary artery. It is a glycoprotein IIb/IIIa inhibitor.[3]
While abciximab has a short plasma half-life, due to its strong affinity for its receptor on the platelets, it may occupy some receptors for weeks. In practice, platelet aggregation gradually returns to normal about 96 to 120 hours after discontinuation of the drug. Abciximab is made from the Fab fragments of an immunoglobulin that targets the glycoprotein IIb/IIIa receptor on the platelet membrane.[4]
- ^ Toronto Notes: Comprehensive medical reference and review for the Medical Council of Canada Qualifying Exam Part I and the United States Medical Licensing Exam Step 2 (32nd ed.). Toronto, Ontario, Canada.: Toronto Notes for Medical Students, Inc. ISBN 978-1-927363-26-3.
- ^ "ReoPro Abciximab" (PDF). Janssen Pharmaceutical Companies. U.S. Food and Drug Administration. August 2019.
- ^ "Abciximab". Drugs.com. Archived from the original on 20 April 2010. Retrieved 13 March 2010.
- ^ "International Nonproprietary Names for Pharmaceutical Substances" (PDF). WHO Drug Information. 7 (4). 1993. Archived from the original (PDF) on June 27, 2004.