Acyl-CoA thioesterase 9

ACOT9
Identifiers
Aliases	ACOT9, ACATE2, MT-ACT48, MTACT48, CGI-16, Acyl-CoA thioesterase 9
External IDs	OMIM: 300862; MGI: 1928939; HomoloGene: 8206; GeneCards: ACOT9; OMA:ACOT9 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	23,766,475 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	154,080,650 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; Achilles tendon; ; left ventricle; ; monocyte; ; right auricle; ; ascending aorta; ; gastric mucosa; ; right ventricle; ; right coronary artery; ; upper lobe of left lung;
	Top expressed in
	endothelial cell of lymphatic vessel; ; hair follicle; ; decidua; ; facial motor nucleus; ; cornea; ; skin of external ear; ; atrioventricular valve; ; granulocyte; ; right kidney; ; gastrula;
	More reference expression data
	n/a
Gene ontology
Molecular function	acetyl-CoA hydrolase activity; hydrolase activity; carboxylic ester hydrolase activity; acyl-CoA hydrolase activity;
Cellular component	mitochondrial matrix; mitochondrion;
Biological process	acyl-CoA metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	23597
	56360
	ENSG00000123130
	ENSMUSG00000025287
	Q9Y305
	Q9R0X4
	NM_001033583; NM_001037171; NM_001330259; NM_012332
	NM_019736; NM_001313718
	NP_001028755; NP_001032248; NP_001317188
	NP_001300647; NP_062710
	Wikidata
View/Edit Human	View/Edit Mouse

Acyl-CoA thioesterase 9 is a protein that is encoded by the human ACOT9 gene. It is a member of the acyl-CoA thioesterase superfamily, which is a group of enzymes that hydrolyze Coenzyme A esters. There is no known function, however it has been shown to act as a long-chain thioesterase at low concentrations, and a short-chain thioesterase at high concentrations.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000123130 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025287 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tillander V, Arvidsson Nordström E, Reilly J, Strozyk M, Van Veldhoven PP, Hunt MC, Alexson SE (Mar 2014). "Acyl-CoA thioesterase 9 (ACOT9) in mouse may provide a novel link between fatty acid and amino acid metabolism in mitochondria". Cellular and Molecular Life Sciences. 71 (5): 933–48. doi:10.1007/s00018-013-1422-1. hdl:10616/41794. PMID 23864032. S2CID 18767370.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000123130 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025287 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid23864032-5] Tillander V, Arvidsson Nordström E, Reilly J, Strozyk M, Van Veldhoven PP, Hunt MC, Alexson SE (Mar 2014). "Acyl-CoA thioesterase 9 (ACOT9) in mouse may provide a novel link between fatty acid and amino acid metabolism in mitochondria". Cellular and Molecular Life Sciences. 71 (5): 933–48. doi:10.1007/s00018-013-1422-1. hdl:10616/41794. PMID 23864032. S2CID 18767370.

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