Adenosine A2B receptor

ADORA2B
Identifiers
Aliases	ADORA2B, ADORA2, adenosine A2b receptor
External IDs	OMIM: 600446; MGI: 99403; HomoloGene: 20167; GeneCards: ADORA2B; OMA:ADORA2B - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	15,975,746 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	62,157,279 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; bronchial epithelial cell; ; retinal pigment epithelium; ; mucosa of sigmoid colon; ; gonad; ; olfactory zone of nasal mucosa; ; mucosa of paranasal sinus; ; nasal epithelium; ; skin of thigh; ; testicle;
	Top expressed in
	gastrula; ; retinal pigment epithelium; ; yolk sac; ; corneal stroma; ; Epithelium of choroid plexus; ; decidua; ; otic placode; ; lumbar subsegment of spinal cord; ; embryo; ; primary oocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled adenosine receptor activity; G protein-coupled receptor activity; signal transducer activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; intracellular anatomical structure; synapse; Schaffer collateral - CA1 synapse; glutamatergic synapse;
Biological process	cellular response to extracellular stimulus; positive regulation of chronic inflammatory response to non-antigenic stimulus; G protein-coupled receptor signaling pathway; G protein-coupled adenosine receptor signaling pathway; excretion; positive regulation of guanylate cyclase activity; adenylate cyclase-activating G protein-coupled receptor signaling pathway; positive regulation of mast cell degranulation; activation of adenylate cyclase activity; cellular defense response; JNK cascade; positive regulation of interleukin-6 production; relaxation of vascular associated smooth muscle; positive regulation of chemokine production; positive regulation of vascular endothelial growth factor production; signal transduction; positive regulation of cGMP-mediated signaling; regulation of synaptic vesicle exocytosis;
	Sources:Amigo / QuickGO
Orthologs
	136
	11541
	ENSG00000170425
	ENSMUSG00000018500
	P29275
	Q60614
	NM_000676
	NM_007413
	NP_000667
	NP_031439
	Wikidata
View/Edit Human	View/Edit Mouse

The adenosine A_2B receptor, also known as ADORA2B, is a G-protein coupled adenosine receptor, and also denotes the human adenosine A_2b receptor gene which encodes it.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170425 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018500 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: ADORA2B adenosine A2b receptor".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170425 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000018500 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: ADORA2B adenosine A2b receptor".

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