Adiponectin

ADIPOQ
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4DOU
Identifiers
Aliases	ADIPOQ, ACDC, ACRP30, ADIPQTL1, ADPN, APM-1, APM1, GBP28, adiponectin, C1Q and collagen domain containing, Adiponectin
External IDs	OMIM: 605441; MGI: 106675; HomoloGene: 3525; GeneCards: ADIPOQ; OMA:ADIPOQ - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q27.3 Start 186,842,704 bp[1] End 186,858,463 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 B1|16 13.96 cM Start 22,965,286 bp[2] End 22,976,778 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in synovial joint pericardium skin of hip adipose tissue subcutaneous adipose tissue abdominal fat parotid gland lactiferous duct Skeletal muscle tissue of rectus abdominis vena cava Top expressed in white adipose tissue lactiferous gland tunica adventitia of aorta brown adipose tissue subcutaneous adipose tissue intercostal muscle ankle joint parotid gland ankle tunica media of zone of aorta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function hormone activity signaling receptor binding cytokine activity sialic acid binding protein homodimerization activity protein binding identical protein binding extracellular matrix structural constituent Cellular component cell surface endoplasmic reticulum collagen extracellular space extracellular region protein-containing complex collagen-containing extracellular matrix Biological process positive regulation of glucose import positive regulation of protein phosphorylation negative regulation of receptor binding low-density lipoprotein particle clearance negative regulation of blood pressure negative regulation of macrophage differentiation negative regulation of synaptic transmission generation of precursor metabolites and energy cellular response to epinephrine stimulus negative regulation of gluconeogenesis regulation of glucose metabolic process circadian rhythm fatty acid oxidation positive regulation of interleukin-8 production glucose metabolic process protein heterotrimerization negative regulation of heterotypic cell-cell adhesion response to ethanol negative regulation of inflammatory response cellular response to cAMP positive regulation of protein kinase A signaling negative regulation of platelet-derived growth factor receptor signaling pathway positive regulation of signal transduction positive regulation of protein metabolic process negative regulation of fat cell differentiation response to linoleic acid detection of oxidative stress glucose homeostasis adiponectin-activated signaling pathway response to tumor necrosis factor positive regulation of blood pressure response to nutrient levels positive regulation of cholesterol efflux negative regulation of MAP kinase activity cellular response to insulin stimulus positive regulation of peptidyl-tyrosine phosphorylation fatty acid beta-oxidation negative regulation of tumor necrosis factor production protein localization to plasma membrane negative regulation of hormone secretion protein homooligomerization response to sucrose positive regulation of metanephric glomerular visceral epithelial cell development positive regulation of renal albumin absorption negative regulation of granulocyte differentiation response to nutrient negative regulation of protein autophosphorylation negative regulation of intracellular protein transport membrane depolarization response to glucose positive regulation of myeloid cell apoptotic process negative regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of metanephric mesenchymal cell migration negative regulation of cell migration positive regulation of fatty acid metabolic process brown fat cell differentiation positive regulation of cAMP-dependent protein kinase activity positive regulation of glycogen (starch) synthase activity negative regulation of transcription, DNA-templated negative regulation of DNA biosynthetic process positive regulation of protein kinase activity response to hypoxia negative regulation of phagocytosis membrane hyperpolarization negative regulation of tumor necrosis factor-mediated signaling pathway positive regulation of monocyte chemotactic protein-1 production response to glucocorticoid response to activity negative regulation of platelet-derived growth factor receptor-alpha signaling pathway positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of ERK1 and ERK2 cascade negative regulation of macrophage derived foam cell differentiation regulation of fatty acid biosynthetic process regulation of signaling receptor activity negative regulation of vascular associated smooth muscle cell proliferation negative regulation of vascular associated smooth muscle cell migration response to bacterium positive regulation of cold-induced thermogenesis negative regulation of cold-induced thermogenesis signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9370 11450 Ensembl ENSG00000181092 ENSMUSG00000022878 UniProt Q15848 Q60994 RefSeq (mRNA) NM_001177800 NM_004797 NM_009605 RefSeq (protein) NP_001171271 NP_004788 NP_033735 Location (UCSC) Chr 3: 186.84 – 186.86 Mb Chr 16: 22.97 – 22.98 Mb PubMed search [3] [4]
Wikidata
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Adiponectin (also referred to as GBP-28, apM1, AdipoQ and Acrp30) is a protein hormone and adipokine, which is involved in regulating glucose levels and fatty acid breakdown.^[5][6] In humans, it is encoded by the ADIPOQ gene and is produced primarily in adipose tissue, but also in muscle and even in the brain.^[7][8]