Adrenocorticotropic hormone (medication)

This article is about Adrenocorticotropic hormone as a medication and diagnostic agent. For as a natural hormone, see Adrenocorticotropic hormone.
Adrenocorticotropic hormone
Clinical data
Trade namesAcortan, Acthar, Acton, Cortigel, Trofocortina
AHFS/Drugs.comInternational Drug Names
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe-OH
PubChem CID
DrugBank
ChemSpider
  • none
ECHA InfoCard100.037.286 Edit this at Wikidata
Chemical and physical data
FormulaC207H308N56O58S
Molar mass4541.14 g·mol−1
Tetracosactide
Clinical data
Trade namesCortrosyn, Synacthen, Nuvacthen
Other namesBa 30920
α1–24 corticotrophin
Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
  • L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl-L-proline
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ECHA InfoCard100.037.286 Edit this at Wikidata
Chemical and physical data
FormulaC136H210N40O31S
Molar mass2933.49 g·mol−1
  • InChI=1S/C136H210N40O31S/c1-75(2)109(127(200)154-71-106(181)156-88(31-13-17-52-137)114(187)158-89(32-14-18-53-138)115(188)159-91(35-21-56-149-134(142)143)116(189)164-96(37-23-58-151-136(146)147)131(204)175-60-25-39-104(175)126(199)173-111(77(5)6)128(201)163-90(33-15-19-54-139)120(193)171-110(76(3)4)129(202)169-101(65-80-43-47-84(180)48-44-80)132(205)176-61-26-40-105(176)133(206)207)172-125(198)103-38-24-59-174(103)130(203)95(34-16-20-55-140)157-107(182)70-153-113(186)99(66-81-68-152-87-30-12-11-29-85(81)87)167-117(190)92(36-22-57-150-135(144)145)160-121(194)98(63-78-27-9-8-10-28-78)166-123(196)100(67-82-69-148-74-155-82)168-118(191)93(49-50-108(183)184)161-119(192)94(51-62-208-7)162-124(197)102(73-178)170-122(195)97(165-112(185)86(141)72-177)64-79-41-45-83(179)46-42-79/h8-12,27-30,41-48,68-69,74-77,86,88-105,109-111,152,177-180H,13-26,31-40,49-67,70-73,137-141H2,1-7H3,(H,148,155)(H,153,186)(H,154,200)(H,156,181)(H,157,182)(H,158,187)(H,159,188)(H,160,194)(H,161,192)(H,162,197)(H,163,201)(H,164,189)(H,165,185)(H,166,196)(H,167,190)(H,168,191)(H,169,202)(H,170,195)(H,171,193)(H,172,198)(H,173,199)(H,183,184)(H,206,207)(H4,142,143,149)(H4,144,145,150)(H4,146,147,151)/t86?,88-,89-,90+,91-,92+,93+,94+,95+,96-,97+,98+,99+,100+,101+,102+,103+,104+,105+,109+,110+,111+/m1/s1 ☒N
  • Key:ZOEFCCMDUURGSE-CQVUSSRSSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Adrenocorticotropic hormone is used as a medication and as diagnostic agent in the ACTH stimulation test.[1][2]: 316, 1165 [3]: 84, 271 

The form that is purified from pig pituitary glands is known as corticotropin[1][2]: 316  is a medication and naturally occurring polypeptide tropic hormone produced and secreted by the anterior pituitary gland.[3]: 84 

The form that is made synthetically is tetracosactide, also known as synacthen,[4] tetracosactrin and cosyntropin.[2]: 1165 [3]: 271 [5] It consists of the first 24 (of a total of 39) amino acids of ACTH and retains full function of the parent peptide.[2]: 1165  Tetracosactide stimulates the release of corticosteroids such as cortisol from the adrenal glands, and is used for the ACTH stimulation test to assess adrenal gland function.[3]: 271 

  1. ^ a b Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 275–. ISBN 978-3-88763-075-1.
  2. ^ a b c d Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. ISBN 978-1-4757-2085-3.
  3. ^ a b c d Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 84–. ISBN 978-94-011-4439-1.
  4. ^ "BNF". NICE.
  5. ^ Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 1005–. ISBN 978-3-88763-075-1.