Adrenomedullin (ADM or AM) is a vasodilator peptide hormone of uncertain significance in human health and disease. It was initially isolated in 1993 from a pheochromocytoma, a tumor of the adrenal medulla: hence the name.[5]
In humans ADM is encoded by the ADM gene. ADM is a peptide expressed by all tissues, and found in the circulation. A similar peptide named adreomedullin2 was reported in rats in 2004 which exhibits a similar function.[6]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000148926 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030790 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Kitamura K, Kato J, Kawamoto M, Tanaka M, Chino N, Kangawa K, Eto T (March 1998). "The intermediate form of glycine-extended adrenomedullin is the major circulating molecular form in human plasma". Biochem. Biophys. Res. Commun. 244 (2): 551–5. doi:10.1006/bbrc.1998.8310. PMID 9514956.
- ^ Fujisawa Y, Nagai Y, Miyatake A, Takei Y, Miura K, Shoukouji T, Nishiyama A, Kimura S, Abe Y (August 2004). "Renal effects of a new member of adrenomedullin family, adrenomedullin2, in rats". Eur. J. Pharmacol. 497 (1): 75–80. doi:10.1016/j.ejphar.2004.06.039. PMID 15321737.