Aequorin

Aequorin 1
Aequorin ribbon diagram from PDB 1ej3 with prosthetic group coelenterazine in blue
Identifiers
Organism	Aequorea victoria (Jellyfish)
Symbol	N/A
UniProt	P07164
Other data
EC number	1.13.12.5
Search for Structures Swiss-model Domains InterPro

Aequorin is a calcium-activated photoprotein isolated from the hydrozoan Aequorea victoria.^[1] Its bioluminescence was studied decades before the protein was isolated from the animal by Osamu Shimomura in 1962.^[2] In the animal, the protein occurs together with the green fluorescent protein to produce green light by resonant energy transfer, while aequorin by itself generates blue light.

Discussions of "jellyfish DNA" that can make "glowing" animals often refer to transgenic animals that express the green fluorescent protein, not aequorin, although both originally derive from the same animal.

Apoaequorin, the protein portion of aequorin, is an ingredient in the dietary supplement Prevagen. The US Federal Trade Commission (FTC) has charged the maker with false advertising for its memory improvement claims.