Age-1

Schematic representation of C.elegans IIS pathway activation

The age-1 gene is located on chromosome 2 in C.elegans. It gained attention in 1983 for its ability to induce long-lived C. elegans mutants.[1] The age-1 mutant, first identified by Michael Klass,[2] was reported to extend mean lifespan by over 50% at 25 °C when compared to the wild type worm (N2) in 1987 by Johnson et al.[1] Development, metabolism, lifespan, among other processes have been associated with age-1 expression.[3] The age-1 gene is known to share a genetic pathway with daf-2 gene that regulates lifespan in worms.[4][5] Additionally, both age-1 and daf-2 mutants are dependent on daf-16 and daf-18 genes to promote lifespan extension.[5][6][7]

Long-lived age-1 mutants are resistant to oxidative stress and UV light.[8] Age-1 mutants also have a higher DNA repair capability than wild-type C. elegans.[8] Knockdown of the nucleotide excision repair gene Xpa-1 increases sensitivity to UV and reduces the life span of the long-lived mutants. These findings support the hypothesis that DNA repair capability underlies longevity.[8]

  1. ^ a b Friedman, D B; Johnson, T E (1988-01-01). "A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility". Genetics. 118 (1): 75–86. doi:10.1093/genetics/118.1.75. ISSN 1943-2631. PMC 1203268. PMID 8608934.
  2. ^ Klass, Michael R. (July 1983). "A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results". Mechanisms of Ageing and Development. 22 (3–4): 279–286. doi:10.1016/0047-6374(83)90082-9. ISSN 0047-6374. PMID 6632998. S2CID 6870538.
  3. ^ "age-1 (gene) - WormBase : Nematode Information Resource". wormbase.org. Retrieved 2021-11-29.
  4. ^ Luo, Yuan (April 2004). "Long-lived worms and aging". Redox Report. 9 (2): 65–69. doi:10.1179/135100004225004733. ISSN 1351-0002. PMID 15231060. S2CID 9251070.
  5. ^ a b Dorman, J B; Albinder, B; Shroyer, T; Kenyon, C (1995-12-01). "The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans". Genetics. 141 (4): 1399–1406. doi:10.1093/genetics/141.4.1399. ISSN 1943-2631. PMC 1206875. PMID 8601482.
  6. ^ Kenyon, Cynthia; Chang, Jean; Gensch, Erin; Rudner, Adam; Tabtiang, Ramon (December 1993). "A C. elegans mutant that lives twice as long as wild type". Nature. 366 (6454): 461–4. Bibcode:1993Natur.366..461K. doi:10.1038/366461a0. ISSN 0028-0836. PMID 8247153. S2CID 4332206.
  7. ^ Larsen, P L; Albert, P S; Riddle, D L (1995-04-01). "Genes that regulate both development and longevity in Caenorhabditis elegans". Genetics. 139 (4): 1567–83. doi:10.1093/genetics/139.4.1567. ISSN 1943-2631. PMC 1206485. PMID 7789761.
  8. ^ a b c Hyun M, Lee J, Lee K, May A, Bohr VA, Ahn B (March 2008). "Longevity and resistance to stress correlate with DNA repair capacity in Caenorhabditis elegans". Nucleic Acids Res. 36 (4): 1380–9. doi:10.1093/nar/gkm1161. PMC 2275101. PMID 18203746.