The age-1 gene is located on chromosome 2 in C.elegans. It gained attention in 1983 for its ability to induce long-lived C. elegans mutants.[1] The age-1 mutant, first identified by Michael Klass,[2] was reported to extend mean lifespan by over 50% at 25 °C when compared to the wild type worm (N2) in 1987 by Johnson et al.[1] Development, metabolism, lifespan, among other processes have been associated with age-1 expression.[3] The age-1 gene is known to share a genetic pathway with daf-2 gene that regulates lifespan in worms.[4][5] Additionally, both age-1 and daf-2 mutants are dependent on daf-16 and daf-18 genes to promote lifespan extension.[5][6][7]
^Klass, Michael R. (July 1983). "A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results". Mechanisms of Ageing and Development. 22 (3–4): 279–286. doi:10.1016/0047-6374(83)90082-9. ISSN0047-6374. PMID6632998. S2CID6870538.