Agouti-related peptide

AGRP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1HYK, 1MR0
Identifiers
Aliases	AGRP, agouti related neuropeptide, AGRT, ART, ASIP2, AgRP
External IDs	OMIM: 602311; MGI: 892013; HomoloGene: 7184; GeneCards: AGRP; OMA:AGRP - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	67,483,547 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	106,364,025 bp
RNA expression pattern
	Top expressed in
	left adrenal gland; ; left adrenal cortex; ; right adrenal gland; ; right adrenal cortex; ; corpus epididymis; ; tail of epididymis; ; right lung; ; caput epididymis; ; upper lobe of left lung; ; monocyte;
	Top expressed in
	median eminence; ; arcuate nucleus; ; blastocyst; ; neural layer of retina; ; morula; ; embryo; ; spermatocyte; ; embryo; ; choroid plexus of fourth ventricle; ; perirhinal cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	neuropeptide hormone activity; signaling receptor binding;
Cellular component	Golgi lumen; extracellular region; neuronal cell body; Golgi apparatus; extracellular space;
Biological process	response to insulin; adult feeding behavior; neuropeptide signaling pathway; regulation of feeding behavior; positive regulation of feeding behavior; circadian rhythm; feeding behavior; eating behavior; maternal process involved in female pregnancy; hormone-mediated signaling pathway; long-day photoperiodism; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	181
	11604
	ENSG00000159723
	ENSMUSG00000005705
	O00253
	P56473
	NM_001138
	NM_001271806; NM_007427
	NP_001129
	NP_001258735; NP_031453
	Wikidata
View/Edit Human	View/Edit Mouse

Agouti-related protein (AgRP), also called agouti-related peptide, is a neuropeptide produced in the brain by the AgRP/NPY neuron. It is synthesized in neuropeptide Y (NPY)-containing cell bodies located in the ventromedial part of the arcuate nucleus in the hypothalamus.^[5] AgRP is co-expressed with NPY and acts to increase appetite and decrease metabolism and energy expenditure. It is one of the most potent and long-lasting of appetite stimulators. In humans, the agouti-related peptide is encoded by the AGRP gene.^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000159723 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000005705 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bäckberg M, Madjid N, Ogren SO, Meister B (June 2004). "Down-regulated expression of agouti-related protein (AGRP) mRNA in the hypothalamic arcuate nucleus of hyperphagic and obese tub/tub mice". Brain Research. Molecular Brain Research. 125 (1–2): 129–39. doi:10.1016/j.molbrainres.2004.03.012. PMID 15193430.
^ Shutter JR, Graham M, Kinsey AC, Scully S, Lüthy R, Stark KL (March 1997). "Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice". Genes & Development. 11 (5): 593–602. doi:10.1101/gad.11.5.593. PMID 9119224.
^ Ollmann MM, Wilson BD, Yang YK, Kerns JA, Chen Y, Gantz I, Barsh GS (October 1997). "Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein". Science. 278 (5335): 135–8. doi:10.1126/science.278.5335.135. PMID 9311920.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000159723 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000005705 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15193430-5] Bäckberg M, Madjid N, Ogren SO, Meister B (June 2004). "Down-regulated expression of agouti-related protein (AGRP) mRNA in the hypothalamic arcuate nucleus of hyperphagic and obese tub/tub mice". Brain Research. Molecular Brain Research. 125 (1–2): 129–39. doi:10.1016/j.molbrainres.2004.03.012. PMID 15193430.

[pmid9119224-6] Shutter JR, Graham M, Kinsey AC, Scully S, Lüthy R, Stark KL (March 1997). "Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice". Genes & Development. 11 (5): 593–602. doi:10.1101/gad.11.5.593. PMID 9119224.

[pmid9311920-7] Ollmann MM, Wilson BD, Yang YK, Kerns JA, Chen Y, Gantz I, Barsh GS (October 1997). "Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein". Science. 278 (5335): 135–8. doi:10.1126/science.278.5335.135. PMID 9311920.

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