Albert Erives

Albert Erives
Born
Adalberto Jorge Erives

(1972-03-04)March 4, 1972
San Fernando, California, U.S.
Alma materCalifornia Institute of Technology, University of California, Berkeley
Known forGene regulation, molecular evolution, genomics
AwardsNSF CAREER award
Scientific career
FieldsBiology
InstitutionsUniversity of Iowa, Dartmouth College
Doctoral advisorMichael Levine

Albert Erives (born March 4, 1972) is a developmental geneticist who studies transcriptional enhancers underlying animal development and diseases of development (cancers). Erives also proposed the pacRNA model for the dual origin of the genetic code and universal homochirality.[1] He is known for work at the intersection of genetics, evolution, developmental biology, and gene regulation.[2][3][4][5] He has worked at the California Institute of Technology, University of California, Berkeley, and Dartmouth College, and is an associate professor at the University of Iowa.

Erives has shown how genes of the nucleocytoplasmic large DNA viruses inform on intermediate steps in the evolution of the linear, chromatinized eukaryotic chromosome and its mechanisms of gene regulation.[6][7]

  1. ^ Erives A (2011). "A Model of Proto-Anti-Codon RNA Enzymes Requiring L-Amino Acid Homochirality". Journal of Molecular Evolution. 73 (1–2): 10–22. Bibcode:2011JMolE..73...10E. doi:10.1007/s00239-011-9453-4. PMC 3223571. PMID 21779963.
  2. ^ Crocker, J.; Tamori, Y. & Erives, A. (2008). "Evolution acts on enhancer organization to fine-tune gradient threshold readouts". PLOS Biology. 6 (11): e263. doi:10.1371/journal.pbio.0060263. PMC 2577699. PMID 18986212.
  3. ^ Brown, S.; Cole, M. & Erives, A.J. (2008). "Evolution of the holozoan ribosome biogenesis regulon". BMC Genomics. 9: 442. doi:10.1186/1471-2164-9-442. PMC 2570694. PMID 18816399.
  4. ^ Erives, A. (2009). "Non-homologous structured CRMs from the Ciona genome" (PDF). J Comput Biol. 16 (2): 369–377. doi:10.1089/cmb.2008.20TT. PMID 19193153. S2CID 15147592. Archived from the original (PDF) on 2020-02-28.
  5. ^ Crocker, J.; Potter, N. & Erives, A. (2010). "Dynamic evolution of precise regulatory encodings creates the clustered site signature of enhancers". Nature Communications. 1 (7): 99. arXiv:1004.1028. Bibcode:2010NatCo...1...99C. doi:10.1038/ncomms1102. PMC 2963808. PMID 20981027.
  6. ^ Talbert, P.; Meers, M.P.; Henikoff, S. (2019). "Old cogs, new tricks: the evolution of gene expression in a chromatin context". Nature Reviews Genetics. 20 (5): 283–297. doi:10.1038/s41576-019-0105-7. PMID 30886348. S2CID 81987181.
  7. ^ Erives, A. (2017). "Phylogenetic analysis of the core histone doublet and DNA topo II genes of Marseilleviridae: evidence of proto-eukaryotic provenance". Epigenetics & Chromatin. 10 (55): 55. doi:10.1186/s13072-017-0162-0. PMC 5704553. PMID 29179736.