| Aldehyde oxidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 | |||||||||
| Identifiers | |||||||||
| EC no. | 1.2.3.1 | ||||||||
| CAS no. | 9029-07-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
| aldehyde oxidase 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | AOX1 | ||||||
| NCBI gene | 316 | ||||||
| HGNC | 553 | ||||||
| OMIM | 602841 | ||||||
| RefSeq | NM_001159 | ||||||
| UniProt | Q06278 | ||||||
| Other data | |||||||
| EC number | 1.2.3.1 | ||||||
| Locus | Chr. 2 q33 | ||||||
| |||||||
Aldehyde oxidase (AO) is a metabolizing enzyme, located in the cytosolic compartment of tissues in many organisms. AO catalyzes the oxidation of aldehydes into carboxylic acid, and in addition, catalyzes the hydroxylation of some heterocycles.[1] It can also catalyze the oxidation of both cytochrome P450 and monoamine oxidase (MAO) intermediate products. AO plays an important role in the metabolism of several drugs.
- ^ Gordon AH, Green DE, Subrahmanyan V (May 1940). "Liver aldehyde oxidase". The Biochemical Journal. 34 (5): 764–74. doi:10.1042/bj0340764. PMC 1265340. PMID 16747217.