Aldolase A

ALDOA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ALD, 2ALD, 4ALD
Identifiers
Aliases	ALDOA, ALDA, GSD12, HEL-S-87p, aldolase, fructose-bisphosphate A, Aldolase A
External IDs	OMIM: 103850; MGI: 87994; HomoloGene: 141054; GeneCards: ALDOA; OMA:ALDOA - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p11.2 Start 30,064,164 bp[1] End 30,070,457 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F3 Start 126,394,406 bp[2] End 126,399,923 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle muscle of thigh skeletal muscle tissue superior frontal gyrus apex of heart prefrontal cortex right frontal lobe primary visual cortex left ventricle right auricle Top expressed in medial head of gastrocnemius muscle ankle vastus lateralis muscle triceps brachii muscle sternocleidomastoid muscle temporal muscle digastric muscle masseter muscle tibialis anterior muscle knee joint More reference expression data BioGPS n/a
Gene ontology Molecular function cytoskeletal protein binding tubulin binding fructose binding protein binding catalytic activity lyase activity actin binding fructose-bisphosphate aldolase activity identical protein binding RNA binding cadherin binding Cellular component cytoplasm M band membrane I band extracellular region actin cytoskeleton extracellular exosome platelet alpha granule lumen nucleus extracellular space cytosol secretory granule lumen tertiary granule lumen ficolin-1-rich granule lumen sperm head Biological process gluconeogenesis glycolytic process muscle cell cellular homeostasis canonical glycolysis actin filament organization fructose metabolic process platelet degranulation fructose 1,6-bisphosphate metabolic process ATP biosynthetic process regulation of cell shape protein homotetramerization striated muscle contraction neutrophil degranulation binding of sperm to zona pellucida Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 226 11674 Ensembl ENSG00000149925 ENSMUSG00000030695 UniProt P04075 P05064 RefSeq (mRNA) NM_000034 NM_001127617 NM_001243175 NM_001243177 NM_184041 NM_184043 NM_001355562 NM_001355563 NM_001355564 NM_001355565 NM_001177307 NM_001177308 NM_007438 RefSeq (protein) NP_001121089 NP_001230106 NP_908930 NP_908932 NP_001170778 NP_001170779 NP_031464 Location (UCSC) Chr 16: 30.06 – 30.07 Mb Chr 7: 126.39 – 126.4 Mb PubMed search [3] [4]
Wikidata
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Aldolase A (ALDOA, or ALDA), also known as fructose-bisphosphate aldolase, is an enzyme that in humans is encoded by the ALDOA gene on chromosome 16.

The protein encoded by this gene is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate (G3P) and dihydroxyacetone phosphate (DHAP). Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing and alternative promoter usage results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 10.^[5]