Aldolase B

ALDOB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1QO5, 1XDL, 1XDM
Identifiers
Aliases	ALDOB, Aldob, Aldo-2, Aldo2, BC016435, ALDB, aldolase, fructose-bisphosphate B
External IDs	OMIM: 612724; MGI: 87995; HomoloGene: 20060; GeneCards: ALDOB; OMA:ALDOB - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	101,449,664 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	49,549,546 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; kidney tubule; ; right lobe of liver; ; renal medulla; ; glomerulus; ; metanephric glomerulus; ; duodenum; ; gallbladder; ; body of pancreas; ; human kidney;
	Top expressed in
	right kidney; ; human kidney; ; left lobe of liver; ; jejunum; ; proximal tubule; ; duodenum; ; ileum; ; migratory enteric neural crest cell; ; epithelium of small intestine; ; intestinal villus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	fructose-1-phosphate aldolase activity; ATPase binding; cytoskeletal protein binding; fructose binding; protein binding; catalytic activity; lyase activity; identical protein binding; fructose-bisphosphate aldolase activity;
Cellular component	cytoplasm; centriolar satellite; microtubule organizing center; extracellular exosome; cytoskeleton; cytosol;
Biological process	gluconeogenesis; positive regulation of ATP-dependent activity; glycolytic process; vacuolar proton-transporting V-type ATPase complex assembly; canonical glycolysis; fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate; fructose 1,6-bisphosphate metabolic process; NADH oxidation; fructose metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	229
	230163
	ENSG00000136872
	ENSMUSG00000028307
	P05062
	Q91Y97
	NM_000035
	NM_144903
	NP_000026
	NP_659152
	Wikidata
View/Edit Human	View/Edit Mouse

Aldolase B also known as fructose-bisphosphate aldolase B or liver-type aldolase is one of three isoenzymes (A, B, and C) of the class I fructose 1,6-bisphosphate aldolase enzyme (EC 4.1.2.13), and plays a key role in both glycolysis and gluconeogenesis. The generic fructose 1,6-bisphosphate aldolase enzyme catalyzes the reversible cleavage of fructose 1,6-bisphosphate (FBP) into glyceraldehyde 3-phosphate and dihydroxyacetone phosphate (DHAP) as well as the reversible cleavage of fructose 1-phosphate (F1P) into glyceraldehyde and dihydroxyacetone phosphate. In mammals, aldolase B is preferentially expressed in the liver, while aldolase A is expressed in muscle and erythrocytes and aldolase C is expressed in the brain. Slight differences in isozyme structure result in different activities for the two substrate molecules: FBP and fructose 1-phosphate. Aldolase B exhibits no preference and thus catalyzes both reactions, while aldolases A and C prefer FBP.^[5]

In humans, aldolase B is encoded by the ALDOB gene located on chromosome 9. The gene is 14,500 base pairs long and contains 9 exons.^[6]^[7]^[8] Defects in this gene have been identified as the cause of hereditary fructose intolerance (HFI).^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000136872 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028307 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dalby AR, Tolan DR, Littlechild JA (November 2001). "The structure of human liver fructose-1,6-bisphosphate aldolase". Acta Crystallogr. D. 57 (Pt 11): 1526–33. doi:10.1107/S0907444901012719. PMID 11679716.
^ "Entrez Gene: ALDOB aldolase B, fructose-bisphosphate".
^ Henry I, Gallano P, Besmond C, Weil D, Mattei MG, Turleau C, Boué J, Kahn A, Junien C (July 1985). "The structural gene for aldolase B (ALDB) maps to 9q13----32". Ann. Hum. Genet. 49 (Pt 3): 173–80. doi:10.1111/j.1469-1809.1985.tb01691.x. PMID 3000275. S2CID 10058239.
^ Tolan DR, Penhoet EE (June 1986). "Characterization of the human aldolase B gene". Mol. Biol. Med. 3 (3): 245–64. PMID 3016456.
^ Cox TM (January 1994). "Aldolase B and fructose intolerance". FASEB J. 8 (1): 62–71. doi:10.1096/fasebj.8.1.8299892. PMID 8299892. S2CID 39102274.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000136872 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028307 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11679716-5] Dalby AR, Tolan DR, Littlechild JA (November 2001). "The structure of human liver fructose-1,6-bisphosphate aldolase". Acta Crystallogr. D. 57 (Pt 11): 1526–33. doi:10.1107/S0907444901012719. PMID 11679716.

[entrez-6] "Entrez Gene: ALDOB aldolase B, fructose-bisphosphate".

[pmid3000275-7] Henry I, Gallano P, Besmond C, Weil D, Mattei MG, Turleau C, Boué J, Kahn A, Junien C (July 1985). "The structural gene for aldolase B (ALDB) maps to 9q13----32". Ann. Hum. Genet. 49 (Pt 3): 173–80. doi:10.1111/j.1469-1809.1985.tb01691.x. PMID 3000275. S2CID 10058239.

[pmid3016456-8] Tolan DR, Penhoet EE (June 1986). "Characterization of the human aldolase B gene". Mol. Biol. Med. 3 (3): 245–64. PMID 3016456.

[pmid8299892-9] Cox TM (January 1994). "Aldolase B and fructose intolerance". FASEB J. 8 (1): 62–71. doi:10.1096/fasebj.8.1.8299892. PMID 8299892. S2CID 39102274.

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