| Aldose reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 | |||||||||
| Identifiers | |||||||||
| EC no. | 1.1.1.21 | ||||||||
| CAS no. | 9028-31-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
In enzymology, aldose reductase (or aldehyde reductase) (EC 1.1.1.21) is an enzyme in humans encoded by the gene AKR1B1. It is an cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides, and primarily known for catalyzing the reduction of glucose to sorbitol, the first step in polyol pathway of glucose metabolism.[1]
- ^ Petrash JM (April 2004). "All in the family: aldose reductase and closely related aldo-keto reductases". Cell. Mol. Life Sci. 61 (7–8): 737–49. doi:10.1007/s00018-003-3402-3. PMC 11138595. PMID 15094999. S2CID 25983505.