Alitretinoin

Alitretinoin
Clinical data
Trade namesPanretin (gel), Toctino (oral)
AHFS/Drugs.comMonograph
MedlinePlusa601012
License data
Routes of
administration
Topical, by mouth
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein bindingHighly bound, no exact figure available[1]
MetabolismLiver (CYP3A4-mediated oxidation, also isomerised to tretinoin)[1]
Elimination half-life2–10 hours[1]
ExcretionUrine (64%), faeces (30%)[1]
Identifiers
  • (2E,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-
    1-cyclohexenyl)nona-2,4,6,8-tetraenoic acid
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.111.081 Edit this at Wikidata
Chemical and physical data
FormulaC20H28O2
Molar mass300.442 g·mol−1
3D model (JSmol)
  • O=C(O)\C=C(\C=C\C=C(/C=C/C1=C(/CCCC1(C)C)C)C)C
  • InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8-,16-14+ checkY
  • Key:SHGAZHPCJJPHSC-ZVCIMWCZSA-N checkY
  (verify)

Alitretinoin, or 9-cis-retinoic acid, is a form of vitamin A. It is also used in medicine as an antineoplastic (anti-cancer) agent developed by Ligand Pharmaceuticals. It is a first generation retinoid. Ligand gained Food and Drug Administration (FDA) approval for alitretinoin in February 1999.

  1. ^ a b c d Cite error: The named reference EMC was invoked but never defined (see the help page).