Alpha-1A adrenergic receptor

ADRA1A
Identifiers
Aliases	ADRA1A, ADRA1C, ADRA1L1, ALPHA1AAR, adrenoceptor alpha 1A
External IDs	OMIM: 104221; MGI: 104773; HomoloGene: 68078; GeneCards: ADRA1A; OMA:ADRA1A - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p21.2 Start 26,748,150 bp[1] End 26,867,278 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 D1 Start 66,872,700 bp[2] End 67,008,617 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver buccal mucosa cell right lung apex of heart left ventricle right ventricle testicle tail of epididymis upper lobe of left lung spleen Top expressed in right kidney superior frontal gyrus primary visual cortex dentate gyrus of hippocampal formation granule cell muscle of thigh brown adipose tissue supraoptic nucleus cerebellar cortex ventricular zone neural tube More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity adrenergic receptor activity protein heterodimerization activity G protein-coupled receptor activity alpha1-adrenergic receptor activity protein binding Cellular component T-tubule nuclear membrane integral component of membrane nucleus integral component of plasma membrane membrane Z discdkac plasma membrane cytoplasm caveola dopaminergic synapse glutamatergic synapse GABA-ergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane Biological process positive regulation of cardiac muscle contraction negative regulation of cell population proliferation response to hormone norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure positive regulation of MAPK cascade intracellular signal transduction positive regulation of ERK1 and ERK2 cascade signal transduction organ growth cell-cell signaling positive regulation of smooth muscle contraction activation of phospholipase C activity pilomotor reflex regulation of vasoconstriction positive regulation of heart rate positive regulation of synaptic transmission, GABAergic positive regulation of systemic arterial blood pressure G protein-coupled receptor signaling pathway urination calcium ion transport into cytosol positive regulation of action potential positive regulation of the force of heart contraction by epinephrine-norepinephrine apoptotic process smooth muscle contraction phospholipase C-activating G protein-coupled receptor signaling pathway adenylate cyclase-activating adrenergic receptor signaling pathway human ageing regulation of cardiac muscle contraction positive regulation of heart rate by epinephrine-norepinephrine positive regulation of protein kinase C signaling negative regulation of Rho protein signal transduction regulation of muscle contraction adult heart development negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure positive regulation of cytosolic calcium ion concentration positive regulation of vasoconstriction negative regulation of autophagy positive regulation of cardiac muscle hypertrophy positive regulation of non-membrane spanning protein tyrosine kinase activity cell growth involved in cardiac muscle cell development regulation of synaptic vesicle exocytosis adenylate cyclase-modulating G protein-coupled receptor signaling pathway neuron-glial cell signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 148 11549 Ensembl ENSG00000120907 ENSMUSG00000045875 UniProt P35348 P97718 RefSeq (mRNA) NM_000680 NM_033302 NM_033303 NM_033304 NM_001322502 NM_001322503 NM_001322504 NM_001271759 NM_001271760 NM_001271761 NM_013461 RefSeq (protein) NP_000671 NP_001309431 NP_001309432 NP_001309433 NP_150645 NP_150646 NP_150647 NP_001258688 NP_001258689 NP_001258690 NP_038489 Location (UCSC) Chr 8: 26.75 – 26.87 Mb Chr 14: 66.87 – 67.01 Mb PubMed search [3] [4]
Wikidata
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The alpha-1A adrenergic receptor (α_1A adrenoreceptor), also known as ADRA1A, formerly known also as the alpha-1C adrenergic receptor,^[5] is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.^[6] There is no longer a subtype α_1C receptor. At one time, there was a subtype known as α_1C, but it was found to be identical to the previously discovered α_1A receptor subtype. To avoid confusion, the naming convention was continued with the letter D.