Alpha-1B adrenergic receptor

ADRA1B
Identifiers
Aliases	ADRA1B, ADRA1, ALPHA1BAR, adrenoceptor alpha 1B
External IDs	OMIM: 104220; MGI: 104774; HomoloGene: 55477; GeneCards: ADRA1B; OMA:ADRA1B - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	159,973,012 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	43,792,037 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; thoracic aorta; ; ascending aorta; ; Descending thoracic aorta; ; popliteal artery; ; tibial arteries; ; prefrontal cortex; ; cingulate gyrus; ; anterior cingulate cortex; ; right lung;
	Top expressed in
	left lobe of liver; ; superior frontal gyrus; ; right ventricle; ; primary visual cortex; ; lateral geniculate nucleus; ; dentate gyrus of hippocampal formation granule cell; ; embryo; ; medial dorsal nucleus; ; nucleus of stria terminalis; ; right kidney;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; adrenergic receptor activity; protein heterodimerization activity; alpha1-adrenergic receptor activity; protein binding;
Cellular component	integral component of membrane; membrane; integral component of plasma membrane; nucleus; nuclear membrane; plasma membrane; cytoplasm; caveola;
Biological process	regulation of muscle contraction; intracellular signal transduction; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure; glucose homeostasis; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; cell-cell signaling; multicellular organism development; adenylate cyclase-activating adrenergic receptor signaling pathway; phospholipase C-activating G protein-coupled receptor signaling pathway; regulation of vasoconstriction; positive regulation of vasoconstriction; regulation of cardiac muscle contraction; cell population proliferation; positive regulation of smooth muscle contraction; positive regulation of MAPK cascade; signal transduction; G protein-coupled receptor signaling pathway; neuron-glial cell signaling;
	Sources:Amigo / QuickGO
Orthologs
	147
	11548
	ENSG00000170214
	ENSMUSG00000050541
	P35368
	P97717
	NM_000679
	NM_001284380; NM_001284381; NM_007416
	NP_000670
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

The alpha-1B adrenergic receptor (α_1B-adrenoreceptor), also known as ADRA1B, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.^[5] The crystal structure of the α_1B-adrenergic receptor has been determined in complex with the inverse agonist (+)-cyclazosin.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170214 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000050541 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cite error: The named reference entrez was invoked but never defined (see the help page).
^ Deluigi M, Morstein L, Schuster M, Klenk C, Merklinger L, Cridge RR, de Zhang LA, Klipp A, Vacca S, Vaid TM, Mittl PR, Egloff P, Eberle SA, Zerbe O, Chalmers DK, Scott DJ, Plückthun A (January 2022). "Crystal structure of the α1B-adrenergic receptor reveals molecular determinants of selective ligand recognition". Nature Communications. 13 (1): 382. Bibcode:2022NatCo..13..382D. doi:10.1038/s41467-021-27911-3. PMC 8770593. PMID 35046410.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170214 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000050541 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] Cite error: The named reference entrez was invoked but never defined (see the help page).

[pmid=35046410-6] Deluigi M, Morstein L, Schuster M, Klenk C, Merklinger L, Cridge RR, de Zhang LA, Klipp A, Vacca S, Vaid TM, Mittl PR, Egloff P, Eberle SA, Zerbe O, Chalmers DK, Scott DJ, Plückthun A (January 2022). "Crystal structure of the α1B-adrenergic receptor reveals molecular determinants of selective ligand recognition". Nature Communications. 13 (1): 382. Bibcode:2022NatCo..13..382D. doi:10.1038/s41467-021-27911-3. PMC 8770593. PMID 35046410.

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