Alpha-2B adrenergic receptor

ADRA2B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CVA
Identifiers
Aliases	ADRA2B, ADRA2L1, ADRA2RL1, ADRARL1, ALPHA2BAR, alpha-2BAR, FAME2, adrenoceptor alpha 2B
External IDs	OMIM: 104260; MGI: 87935; HomoloGene: 553; GeneCards: ADRA2B; OMA:ADRA2B - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	96,116,571 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	127,209,141 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; gastrocnemius muscle; ; left ventricle; ; right lobe of liver; ; spleen; ; subcutaneous adipose tissue; ; muscle of thigh; ; tibial nerve; ; ascending aorta; ; gastric mucosa;
	Top expressed in
	right kidney; ; proximal tubule; ; human kidney; ; yolk sac; ; decidua; ; embryo; ; embryo; ; hepatobiliary system; ; liver; ; secondary oocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; alpha2-adrenergic receptor activity; adrenergic receptor activity; epinephrine binding; protein binding;
Cellular component	integral component of membrane; plasma membrane; membrane; integral component of plasma membrane; intracellular anatomical structure; cell surface;
Biological process	platelet activation; female pregnancy; G protein-coupled receptor signaling pathway; positive regulation of blood pressure; adrenergic receptor signaling pathway; regulation of vasoconstriction; regulation of vascular associated smooth muscle contraction; positive regulation of uterine smooth muscle contraction; regulation of smooth muscle contraction; signal transduction; activation of protein kinase B activity; negative regulation of epinephrine secretion; cell-cell signaling; adenylate cyclase-activating adrenergic receptor signaling pathway; positive regulation of neuron differentiation; negative regulation of norepinephrine secretion; positive regulation of MAPK cascade; receptor transactivation; adenylate cyclase-modulating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	151
	11552
	ENSG00000274286
	ENSMUSG00000058620
	P18089
	P30545
	NM_000682
	NM_009633
	NP_000673
	NP_033763
	Wikidata
View/Edit Human	View/Edit Mouse

The alpha-2B adrenergic receptor (α_2B adrenoceptor), is a G-protein coupled receptor. It is a subtype of the adrenergic receptor family. The human gene encoding this receptor has the symbol ADRA2B.^[5] ADRA2B orthologs^[6] have been identified in several mammals.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000274286 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000058620 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cite error: The named reference entrez was invoked but never defined (see the help page).
^ "OrthoMaM phylogenetic marker: ADRA2B coding sequence".^{[permanent dead link]}

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000274286 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000058620 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] Cite error: The named reference entrez was invoked but never defined (see the help page).

[OrthoMaM-6] "OrthoMaM phylogenetic marker: ADRA2B coding sequence".^{[permanent dead link]}

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