Ambient ionization

Diagram of ambient ionization in mass spectrometry indicating desorption/extraction (spray, heat, laser), optional post-ionization (electrospray, chemical ionization, plasma), ion formation, and entry into the vacuum of the mass spectrometer.

Ambient ionization is a form of ionization in which ions are formed in an ion source outside the mass spectrometer without sample preparation or separation.[1][2][3][4] Ions can be formed by extraction into charged electrospray droplets, thermally desorbed and ionized by chemical ionization, or laser desorbed or ablated and post-ionized before they enter the mass spectrometer.[5]

  1. ^ Domin, Marek; Cody, Robert (2014). Ambient Ionization Mass Spectrometry. RSC (Royal Society of Chemistry). doi:10.1039/9781782628026. ISBN 978-1-84973-926-9.
  2. ^ Cooks, R. Graham; Ouyang, Zheng; Takats, Zoltan; Wiseman, Justin M. (2006). "Ambient Mass Spectrometry". Science. 311 (5767): 1566–70. Bibcode:2006Sci...311.1566C. doi:10.1126/science.1119426. PMID 16543450. S2CID 22007354.
  3. ^ Monge, María Eugenia; Harris, Glenn A.; Dwivedi, Prabha; Fernández, Facundo M. (2013). "Mass Spectrometry: Recent Advances in Direct Open Air Surface Sampling/Ionization". Chemical Reviews. 113 (4): 2269–2308. doi:10.1021/cr300309q. ISSN 0009-2665. PMID 23301684.
  4. ^ Huang, Min-Zong; Yuan, Cheng-Hui; Cheng, Sy-Chyi; Cho, Yi-Tzu; Shiea, Jentaie (2010). "Ambient Ionization Mass Spectrometry". Annual Review of Analytical Chemistry. 3 (1): 43–65. Bibcode:2010ARAC....3...43H. doi:10.1146/annurev.anchem.111808.073702. ISSN 1936-1327. PMID 20636033.
  5. ^ Paine, Martin R. L.; Barker, Philip J.; Blanksby, Stephen J. (15 January 2014). "Ambient ionisation mass spectrometry for the characterisation of polymers and polymer additives: a review". Analytica Chimica Acta. 808: 70–82. Bibcode:2014AcAC..808...70P. doi:10.1016/j.aca.2013.10.001. PMID 24370094.