Amine oxidase (copper-containing)

Copper amine oxidase, enzyme domain
Crystal structure of a copper-containing benzylamine oxidase from Hansenula polymorpha.[1]
Identifiers
Symbol	Cu_amine_oxid
Pfam	PF01179
InterPro	IPR015798
PROSITE	PDOC00895
SCOP2	1oac / SCOPe / SUPFAM
Membranome	252
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Copper amine oxidase N-terminal domain
crystal structure of e. coli amine oxidase anaerobically reduced with beta-phenylethylamine
Identifiers
Symbol	Cu_amine_oxidN1
Pfam	PF07833
InterPro	IPR012854
SCOP2	1spu / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Copper amine oxidase, N2 domain
crystal structure of a eukaryotic (pea seedling) copper-containing amine oxidase at 2.2a resolution
Identifiers
Symbol	Cu_amine_oxidN2
Pfam	PF02727
Pfam clan	CL0047
InterPro	IPR015800
PROSITE	PDOC00895
SCOP2	1oac / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Copper amine oxidase, N3 domain
crystal structure of hansenula polymorpha amine oxidase in complex with xe to 1.6 angstroms
Identifiers
Symbol	Cu_amine_oxidN3
Pfam	PF02728
Pfam clan	CL0047
InterPro	IPR015802
PROSITE	PDOC00895
SCOP2	1oac / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Amine oxidase (copper-containing) (AOC) (EC 1.4.3.21 and EC 1.4.3.22; formerly EC 1.4.3.6) is a family of amine oxidase enzymes which includes both primary-amine oxidase and diamine oxidase; these enzymes catalyze the oxidation of a wide range of biogenic amines including many neurotransmitters, histamine and xenobiotic amines. They act as a disulphide-linked homodimer. They catalyse the oxidation of primary amines to aldehydes, with the subsequent release of ammonia and hydrogen peroxide, which requires one copper ion per subunit and topaquinone as cofactor:^[2]

RCH₂NH₂ + H₂O + O₂ ${\displaystyle \rightleftharpoons }$ RCHO + NH₃ + H₂O₂

The 3 substrates of this enzyme are primary amines (RCH2NH2), H₂O, and O₂, whereas its 3 products are RCHO, NH₃, and H₂O₂.

Copper-containing amine oxidases are found in bacteria, fungi, plants and animals. In prokaryotes, the enzyme enables various amine substrates to be used as sources of carbon and nitrogen.^[3][4]

This enzyme belongs to oxidoreductases, specifically those acting on the CH-NH2 group of donors with oxygen as acceptor. The systematic name of this enzyme class is amine:oxygen oxidoreductase (deaminating) (copper-containing). This enzyme participates in 8 metabolic pathways: urea cycle and metabolism of amino groups, glycine, serine and threonine metabolism, histidine metabolism, tyrosine metabolism, phenylalanine metabolism, tryptophan metabolism, beta-alanine metabolism, and alkaloid biosynthesis ii. It has 2 cofactors: copper, and PQQ.