Amyloid-related imaging abnormalities

Amyloid-related imaging abnormalities
Other namesARIA
Two MRI scans demonstrating the difference between ARIA-E (left) and ARIA-H in the parietal region (right)
SpecialtyRadiology, neurology

Amyloid-related imaging abnormalities (ARIA) are abnormal differences seen in magnetic resonance imaging of the brain in patients with Alzheimer's disease. ARIA is associated with anti-amyloid drugs, particularly human monoclonal antibodies such as aducanumab.[1] There are two types of ARIA: ARIA-E and ARIA-H. The phenomenon was first seen in trials of bapineuzumab.[2]

  1. ^ Sperling, Reisa A.; Jack, Clifford R.; Black, Sandra E.; Frosch, Matthew P.; Greenberg, Steven M.; Hyman, Bradley T.; Scheltens, Philip; Carrillo, Maria C.; Thies, William (2016-12-12). "Amyloid Related Imaging Abnormalities (ARIA) in Amyloid Modifying Therapeutic Trials: Recommendations from the Alzheimer's Association Research Roundtable Workgroup". Alzheimer's & Dementia. 7 (4): 367–385. doi:10.1016/j.jalz.2011.05.2351. ISSN 1552-5260. PMC 3693547. PMID 21784348.
  2. ^ DiFrancesco, Jacopo C.; Longoni, Martina; Piazza, Fabrizio (2015-09-25). "Anti-Aβ Autoantibodies in Amyloid Related Imaging Abnormalities (ARIA): Candidate Biomarker for Immunotherapy in Alzheimer's Disease and Cerebral Amyloid Angiopathy". Frontiers in Neurology. 6: 207. doi:10.3389/fneur.2015.00207. ISSN 1664-2295. PMC 4585101. PMID 26441825.