Ancestral reconstruction

Ancestral reconstruction (also known as Character Mapping or Character Optimization) is the extrapolation back in time from measured characteristics of individuals, populations, or species to their common ancestors. It is an important application of phylogenetics, the reconstruction and study of the evolutionary relationships among individuals, populations or species to their ancestors. In the context of evolutionary biology, ancestral reconstruction can be used to recover different kinds of ancestral character states of organisms that lived millions of years ago.[1] These states include the genetic sequence (ancestral sequence reconstruction), the amino acid sequence of a protein, the composition of a genome (e.g., gene order), a measurable characteristic of an organism (phenotype), and the geographic range of an ancestral population or species (ancestral range reconstruction). This is desirable because it allows us to examine parts of phylogenetic trees corresponding to the distant past, clarifying the evolutionary history of the species in the tree. Since modern genetic sequences are essentially a variation of ancient ones, access to ancient sequences may identify other variations and organisms which could have arisen from those sequences.[2] In addition to genetic sequences, one might attempt to track the changing of one character trait to another, such as fins turning to legs.

Non-biological applications include the reconstruction of the vocabulary or phonemes of ancient languages,[3] and cultural characteristics of ancient societies such as oral traditions[4] or marriage practices.[5]

Ancestral reconstruction relies on a sufficiently realistic statistical model of evolution to accurately recover ancestral states. These models use the genetic information already obtained through methods such as phylogenetics to determine the route that evolution has taken and when evolutionary events occurred.[6] No matter how well the model approximates the actual evolutionary history, however, one's ability to accurately reconstruct an ancestor deteriorates with increasing evolutionary time between that ancestor and its observed descendants. Additionally, more realistic models of evolution are inevitably more complex and difficult to calculate. Progress in the field of ancestral reconstruction has relied heavily on the exponential growth of computing power and the concomitant development of efficient computational algorithms (e.g., a dynamic programming algorithm for the joint maximum likelihood reconstruction of ancestral sequences).[7] Methods of ancestral reconstruction are often applied to a given phylogenetic tree that has already been inferred from the same data. While convenient, this approach has the disadvantage that its results are contingent on the accuracy of a single phylogenetic tree. In contrast, some researchers[8] advocate a more computationally intensive Bayesian approach that accounts for uncertainty in tree reconstruction by evaluating ancestral reconstructions over many trees.

  1. ^ Cite error: The named reference Omland1999 was invoked but never defined (see the help page).
  2. ^ Cite error: The named reference CaiPei2004 was invoked but never defined (see the help page).
  3. ^ Cite error: The named reference PlatnickCameron1977 was invoked but never defined (see the help page).
  4. ^ Cite error: The named reference BentleyTehrani2013 was invoked but never defined (see the help page).
  5. ^ Cite error: The named reference MichalakWalker2011 was invoked but never defined (see the help page).
  6. ^ Cite error: The named reference Brooks1999 was invoked but never defined (see the help page).
  7. ^ Cite error: The named reference PupkoPe2000 was invoked but never defined (see the help page).
  8. ^ Cite error: The named reference PagelMeade2004 was invoked but never defined (see the help page).