Angiolathyrism

Angiolathyrism
SpecialtyNeurology
SymptomsWeakness, fatigue, paralysis of the legs, atrophy of leg muscles
Usual onsetGradual
DurationPermanent
TypesNeurolathyrism
Diagnostic methodBased on symptoms and diet
FrequencyRare

Angiolathyrism is a form of lathyrism disease. It is mainly caused the consumption of Lathyrus sativus (also known as grass pea) and to a lesser degree by Lathyrus cicera, Lathyrus ochrus and Lathyrus clymenum[1] containing the toxin ODAP.[2] The main chemical responsible is β-Aminopropionitrile, which prevents collagen cross-linking, thus making the blood vessel, especially the tunica media, weak. This can result in Cystic medial necrosis or a picture similar to Marfan syndrome. The damaged vessels are at an increased risk of dissection.[citation needed]

Unlike osteolathyrism, the blood vessels are affected instead of bone. However it is caused by similar action and is typically associated with the other forms of lathyrism.[citation needed]

  1. ^ "Medical problems caused by plants: Lathyrism" Archived 2012-02-04 at the Wayback Machine at Prince Leopold Institute of Tropical Medicine online database
  2. ^ "Lathyrism". Egton Medical Information Systems Limited. 22 March 2010.