Protein found in humans
Anion exchange protein 2 (AE2) is a membrane transport protein that in humans is encoded by the SLC4A2 gene .[ 5] [ 6] AE2 is functionally similar to the Band 3 Cl− /HCO3− exchange protein.
Mice have been used to explore the function of AE2. AE2 contributes to basolateral membrane HCO3 − transport in the gastrointestinal tract .[ 7] AE2 is required for spermiogenesis in mice.[ 8] AE2 is required for normal osteoclast function.[ 9] [ 10] The activity of AE2 is sensitive to pH .[ 11]
AE3 has been suggested as a target for prevention of diabetic vasculopathy .[ 12]
^ a b c GRCh38: Ensembl release 89: ENSG00000164889 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028962 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Tanner MJ (January 1993). "Molecular and cellular biology of the erythrocyte anion exchanger (AE1)". Seminars in Hematology . 30 (1): 34–57. PMID 8434259 .
^ "Entrez Gene: SLC4A2 solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)" .
^ Gawenis LR, Bradford EM, Alper SL, Prasad V, Shull GE (April 2010). "AE2 Cl-/HCO3- exchanger is required for normal cAMP-stimulated anion secretion in murine proximal colon" . American Journal of Physiology. Gastrointestinal and Liver Physiology . 298 (4): G493–G503. doi :10.1152/ajpgi.00178.2009 . PMC 2853300 . PMID 20110461 .
^ Medina JF, Recalde S, Prieto J, Lecanda J, Saez E, Funk CD, et al. (December 2003). "Anion exchanger 2 is essential for spermiogenesis in mice" . Proceedings of the National Academy of Sciences of the United States of America . 100 (26): 15847–15852. Bibcode :2003PNAS..10015847M . doi :10.1073/pnas.2536127100 . PMC 307656 . PMID 14673081 .
^ Wu J, Glimcher LH, Aliprantis AO (November 2008). "HCO3-/Cl- anion exchanger SLC4A2 is required for proper osteoclast differentiation and function" . Proceedings of the National Academy of Sciences of the United States of America . 105 (44): 16934–16939. Bibcode :2008PNAS..10516934W . doi :10.1073/pnas.0808763105 . PMC 2579356 . PMID 18971331 .
^ Josephsen K, Praetorius J, Frische S, Gawenis LR, Kwon TH, Agre P, et al. (February 2009). "Targeted disruption of the Cl-/HCO3- exchanger Ae2 results in osteopetrosis in mice" . Proceedings of the National Academy of Sciences of the United States of America . 106 (5): 1638–1641. doi :10.1073/pnas.0811682106 . PMC 2635809 . PMID 19164575 .
^ Stewart AK, Kurschat CE, Vaughan-Jones RD, Alper SL (March 2009). "Putative re-entrant loop 1 of AE2 transmembrane domain has a major role in acute regulation of anion exchange by pH" . The Journal of Biological Chemistry . 284 (10): 6126–6139. doi :10.1074/jbc.M802051200 . PMC 2649077 . PMID 19103596 .
^ Huang QR, Li Q, Chen YH, Li L, Liu LL, Lei SH, et al. (June 2010). "Involvement of anion exchanger-2 in apoptosis of endothelial cells induced by high glucose through an mPTP-ROS-Caspase-3 dependent pathway". Apoptosis . 15 (6): 693–704. doi :10.1007/s10495-010-0477-9 . PMID 20180022 . S2CID 25917589 .