Ankyrin-2

ANK2
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4D8O, 4RLV, 4RLY
Identifiers
Aliases	ANK2, ANK-2, LQT4, brank-2, ankyrin 2, neuronal, ankyrin 2
External IDs	OMIM: 106410; HomoloGene: 81655; GeneCards: ANK2; OMA:ANK2 - orthologs
Gene ontology Molecular function protein-macromolecule adaptor activity spectrin binding transmembrane transporter binding ATPase binding structural constituent of cytoskeleton protein binding enzyme binding protein kinase binding phosphorylation-dependent protein binding Cellular component M band cytoplasm cytosol postsynaptic membrane membrane intercalated disc T-tubule synapse intracellular anatomical structure cell junction basolateral plasma membrane Z discdkac apical plasma membrane membrane raft neuron projection sarcolemma A band cytoskeleton costamere mitochondrion lysosome endosome early endosome recycling endosome plasma membrane axon initial segment Biological process positive regulation of potassium ion transmembrane transporter activity protein localization to organelle positive regulation of cation channel activity regulation of cardiac muscle contraction by calcium ion signaling regulation of calcium ion transport regulation of protein stability regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion positive regulation of potassium ion transport regulation of release of sequestered calcium ion into cytosol SA node cell action potential protein stabilization ventricular cardiac muscle cell action potential cellular calcium ion homeostasis positive regulation of calcium ion transmembrane transporter activity nervous system development regulation of heart rate protein localization to M-band endoplasmic reticulum to Golgi vesicle-mediated transport regulation of cardiac muscle cell contraction protein localization to T-tubule positive regulation of gene expression protein localization to cell surface paranodal junction assembly atrial cardiac muscle cell action potential sarcoplasmic reticulum calcium ion transport SA node cell to atrial cardiac muscle cell communication membrane depolarization during SA node cell action potential atrial cardiac muscle cell to AV node cell communication regulation of cardiac muscle contraction protein localization to endoplasmic reticulum response to methylmercury regulation of SA node cell action potential regulation of heart rate by cardiac conduction atrial septum development regulation of calcium ion transmembrane transporter activity signal transduction regulation of atrial cardiac muscle cell action potential T-tubule organization positive regulation of calcium ion transport regulation of ventricular cardiac muscle cell membrane repolarization cytoskeleton organization protein localization to plasma membrane endocytosis protein transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 287 n/a Ensembl ENSG00000145362 n/a UniProt Q01484 n/a RefSeq (mRNA) NM_001127493 NM_001148 NM_020977 n/a RefSeq (protein) NP_001120965 NP_001139 NP_066187 NP_001341154 NP_001341157 NP_001341159 NP_001341160 NP_001341161 NP_001341164 NP_001341165 NP_001341166 NP_001341168 NP_001341169 NP_001341170 NP_001341171 NP_001341172 NP_001341173 NP_001341174 NP_001341175 NP_001341178 NP_001341181 NP_001341182 NP_001341183 NP_001341184 NP_001341185 NP_001341186 NP_001341187 NP_001341189 NP_001341190 NP_001341191 NP_001341193 NP_001341194 NP_001341195 NP_001341196 NP_001341197 NP_001341198 NP_001341199 NP_001341200 NP_001341201 NP_001341202 NP_001341203 NP_001341204 NP_001341205 NP_001341206 NP_001341207 NP_001341208 NP_001341209 NP_001341210 NP_001341211 n/a Location (UCSC) n/a n/a PubMed search [1] n/a
Wikidata
View/Edit Human

Ankyrin-2, also known as Ankyrin-B, and Brain ankyrin, is a protein which in humans is encoded by the ANK2 gene.^[2][3] Ankyrin-2 is ubiquitously expressed, but shows high expression in cardiac muscle. Ankyrin-2 plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in cardiomyocytes, as well as in costamere structures. Mutations in ANK2 cause a dominantly-inherited, cardiac arrhythmia syndrome known as long QT syndrome 4^[4] as well as sick sinus syndrome; mutations have also been associated to a lesser degree with hypertrophic cardiomyopathy. Alterations in ankyrin-2 expression levels are observed in human heart failure.