Annexin A1

ANXA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1QLS, 1AIN, 1BO9
Identifiers
Aliases	ANXA1, ANX1, LPC1, annexin A1
External IDs	OMIM: 151690; MGI: 96819; HomoloGene: 563; GeneCards: ANXA1; OMA:ANXA1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	73,170,393 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	20,368,308 bp
RNA expression pattern
	Top expressed in
	oral cavity; ; mucosa of pharynx; ; gums; ; gingival epithelium; ; body of tongue; ; amniotic fluid; ; Achilles tendon; ; palpebral conjunctiva; ; epithelium of nasopharynx; ; nasal epithelium;
	Top expressed in
	stroma of bone marrow; ; granulocyte; ; umbilical cord; ; corneal stroma; ; epithelium of lens; ; endothelial cell of lymphatic vessel; ; skin of abdomen; ; tibiofemoral joint; ; skin of external ear; ; conjunctival fornix;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; protein-macromolecule adaptor activity; structural molecule activity; calcium-dependent protein binding; double-stranded DNA helicase activity; signaling receptor binding; phospholipid binding; ATP-dependent DNA/DNA annealing activity; helicase activity; phospholipase A2 inhibitor activity; metal ion binding; protein homodimerization activity; single-stranded DNA binding; protein binding; calcium-dependent phospholipid binding; phospholipase inhibitor activity; single-stranded RNA binding; cadherin binding involved in cell-cell adhesion; DNA/DNA annealing activity;
Cellular component	cytoplasm; endosome; membrane; focal adhesion; extracellular region; nucleus; cell projection; mitochondrial membranes; cilium; cornified envelope; cell surface; extrinsic component of external side of plasma membrane; apical plasma membrane; motile cilium; extracellular exosome; early endosome membrane; lateral plasma membrane; plasma membrane; extrinsic component of endosome membrane; nucleoplasm; early endosome; endosome membrane; extrinsic component of membrane; vesicle; mast cell granule; basolateral plasma membrane; sarcolemma; phagocytic cup; cytoplasmic vesicle membrane; cytoplasmic vesicle; extracellular space; cytosol; actin filament; protein-containing complex; collagen-containing extracellular matrix; synaptic membrane;
Biological process	response to interleukin-1; adaptive immune response; estrous cycle; hepatocyte differentiation; prostate gland development; cell surface receptor signaling pathway; myoblast migration involved in skeletal muscle regeneration; granulocyte chemotaxis; endocrine pancreas development; gliogenesis; negative regulation of T-helper 2 cell differentiation; neutrophil homeostasis; prolactin secretion; positive regulation of wound healing; negative regulation of phospholipase A2 activity; insulin secretion; regulation of leukocyte migration; positive regulation of G1/S transition of mitotic cell cycle; cellular response to glucocorticoid stimulus; positive regulation of T cell proliferation; phagocytosis; innate immune response; inflammatory response; arachidonic acid secretion; negative regulation of exocytosis; monocyte chemotaxis; immune system process; positive regulation of T-helper 1 cell differentiation; regulation of interleukin-1 production; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; negative regulation of apoptotic process; positive regulation of prostaglandin biosynthetic process; positive regulation of vesicle fusion; positive regulation of interleukin-2 production; regulation of inflammatory response; regulation of cell shape; alpha-beta T cell differentiation; response to hormone; actin cytoskeleton reorganization; response to estradiol; response to organic cyclic compound; response to peptide hormone; response to glucocorticoid; keratinocyte differentiation; positive regulation of neutrophil apoptotic process; DNA rewinding; response to corticosteroid; DNA duplex unwinding; peptide cross-linking; regulation of cell population proliferation; neutrophil clearance; positive regulation of apoptotic process; regulation of hormone secretion; negative regulation of protein secretion; response to X-ray; signal transduction; cellular response to hydrogen peroxide; cell-cell adhesion; G protein-coupled receptor signaling pathway; cytokine-mediated signaling pathway; cellular response to vascular endothelial growth factor stimulus; positive regulation of cell migration involved in sprouting angiogenesis; negative regulation of catalytic activity;
	Sources:Amigo / QuickGO
Orthologs
	301
	16952
	ENSG00000135046
	ENSMUSG00000024659
	P04083; Q5T3N0
	P10107
	NM_000700
	NM_010730
	NP_000691
	NP_034860
	Wikidata
View/Edit Human	View/Edit Mouse

Annexin A1, also known as lipocortin I, is a protein that is encoded by the ANXA1 gene in humans.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135046 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024659 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wallner BP, Mattaliano RJ, Hession C, Cate RL, Tizard R, Sinclair LK, et al. (1986). "Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity". Nature. 320 (6057): 77–81. Bibcode:1986Natur.320...77W. doi:10.1038/320077a0. PMID 2936963. S2CID 4332606.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135046 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024659 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2936963-5] Wallner BP, Mattaliano RJ, Hession C, Cate RL, Tizard R, Sinclair LK, et al. (1986). "Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity". Nature. 320 (6057): 77–81. Bibcode:1986Natur.320...77W. doi:10.1038/320077a0. PMID 2936963. S2CID 4332606.

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