Antigenic drift

Not to be confused with Antigenic shift or Genetic drift.

Antigenic drift is a kind of genetic variation in viruses, arising from the accumulation of mutations in the virus genes that code for virus-surface proteins that host antibodies recognize. This results in a new strain of virus particles that is not effectively inhibited by the antibodies that prevented infection by previous strains. This makes it easier for the changed virus to spread throughout a partially immune population. Antigenic drift occurs in both influenza A and influenza B viruses.

(Confusion can arise with two very similar terms, antigenic shift and genetic drift. Antigenic shift is a closely related process; it refers to the more dramatic changes in the virus's surface proteins when the genetic material from two or more viruses mix together. Genetic drift is very different and much more broadly applicable; it refers to the gradual accumulation in any DNA sequence of random mutational changes that do not interfere with the DNA's function and thus that are not seen by natural selection.)

The immune system recognizes viruses when antigens on the surfaces of virus particles bind to immune receptors that are specific for these antigens. These receptors can be antibodies in the bloodstream or similar proteins on the surfaces of immune-system cells. This recognition is quite precise, like a key recognizing a lock. After an infection or after vaccination, the body produces many more of these virus-specific immune receptors, which prevent re-infection by this particular strain of the virus; this is called acquired immunity. However, viral genomes are constantly mutating, producing new forms of these antigens. If one of these new forms of an antigen is sufficiently different from the old antigen, it will no longer bind to the antibodies or immune-cell receptors, allowing the mutant virus to infect people who were immune to the original strain of the virus because of prior infection or vaccination.

In 1940s, Maurice Hilleman discovered antigenic drift, which is the most common way that influenza viruses change.[1][2][3][4] A second type of change is antigenic shift, also discovered by Hilleman,[1][2] where the virus acquires a completely new version of one of its surface-protein genes from a distantly related influenza virus. The rate of antigenic drift is dependent on two characteristics: the duration of the epidemic, and the strength of host immunity. A longer epidemic allows for selection pressure to continue over an extended period of time and stronger host immune responses increase selection pressure for development of novel antigens.[5]

  1. ^ a b Oransky, Ivan (2005-05-14). "Maurice R Hilleman". The Lancet. 365 (9472): 1682. doi:10.1016/S0140-6736(05)66536-1. ISSN 0140-6736. PMID 15912596. S2CID 46630955.
  2. ^ a b Kurth, Reinhard (April 2005). "Maurice R. Hilleman (1919–2005)". Nature. 434 (7037): 1083. doi:10.1038/4341083a. ISSN 1476-4687. PMID 15858560.
  3. ^ D. J. D. Earn; J. Dushoff; S. A. Levin (2002). "Ecology and Evolution of the Flu". Trends in Ecology and Evolution. 17 (7): 334–340. doi:10.1016/S0169-5347(02)02502-8.
  4. ^ A. W. Hampson (2002). "Influenza virus antigens and antigenic drift". In C. W. Potter (ed.). Influenza. Elsevier Science B. V. pp. 49–86. ISBN 978-0-444-82461-5.
  5. ^ Boni, T; S. Cobey; P. Beerli; M. Pascual (2006). "Epidemic dynamics and antigenic evolution in a single season of influenza A". Proceedings of the Royal Society B. 273 (1592): 1307–1316. doi:10.1098/rspb.2006.3466. PMC 1560306. PMID 16777717.