Aortic sac

Aortic sac
Diagrams to show the development of the septum of the aortic bulb and of the ventricles.
Transverse sections through the aortic bulb to show the growth of the aortic septum. The lowest section is on the left, the highest on the right of the figure.
Details
Days37
Precursorneural crest
Identifiers
TA98A12.2.03.004
TA23992
TEsac_by_E4.0.3.5.0.3.12 E4.0.3.5.0.3.12
FMA3740
Anatomical terminology

The aortic sac or aortic bulb[1] is a dilated structure in mammalian embryos, lined by endothelial cells and is the most distal part of the truncus arteriosus.[2] It is the primordial vascular channel from which the aortic arches arise (and eventually the dorsal aortae) and is homologous to the ventral aorta of gill-bearing vertebrates. The aortic sac eventually forms right and left horns, which subsequently give rise to the brachiocephalic trunk and the proximal segment of the arch of aorta, respectively.[2]

Genes HAND2 (dHAND) and HAND1 (eHAND) are expressed during the development of the aortic bulb and the arteries which arise from it.[3] The protein encoded by these genes belong to the basic helix-loop-helix family of transcription factors.

  1. ^ Annalisa Berta, James L. Sumich, Kit M. Kovacs. Marine Mammals: Evolutionary Biology. Academic Press, 2006; page 240.
  2. ^ a b Sadler, T. W. (2019). Langman's Medical Embryology (14th ed.). Philadelphia. p. 206. ISBN 978-1-4963-8390-7. OCLC 1042400100.{{cite book}}: CS1 maint: location missing publisher (link)
  3. ^ Richard P. Harvey, Nadia Rosenthal (ed). Heart Development. Gulf Professional Publishing, 1999; page 150-151.