Identifiers | |
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3D model (JSmol)
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ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.041.969 |
PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C79H131N31O24S4 | |
Molar mass | 2027.33874 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Apamin Preproprotein | |||||||
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Identifiers | |||||||
Symbol | Apamin | ||||||
CAS number | |||||||
NCBI gene | 406135 | ||||||
UniProt | P01500 | ||||||
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Apamin is an 18 amino acid globular peptide neurotoxin found in apitoxin (bee venom).[2] Dry bee venom consists of 2–3% of apamin.[3] Apamin selectively blocks SK channels, a type of Ca2+-activated K+ channel expressed in the central nervous system. Toxicity is caused by only a few amino acids, in particular cysteine1, lysine4, arginine13, arginine14 and histidine18. These amino acids are involved in the binding of apamin to the Ca2+-activated K+ channel. Due to its specificity for SK channels, apamin is used as a drug in biomedical research to study the electrical properties of SK channels and their role in the afterhyperpolarizations occurring immediately following an action potential.[4]